HEALTH DISPARITIES RESEARCH THROUGH INTERNATIONAL EXCHANGE

通过国际交流进行健康差异研究

• 批准号: 8776970
• 负责人: WINSTON ANTHONY ANDERSON
• 金额: $ 25.67万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-12-01 至 2018-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8776970
• 关键词: Affect; Africa; Air; Apoptosis; Behavioral Sciences; Bioinformatics; Biological Factors; Blood; Caribbean region; Cell physiology; Chemicals; Clinic; Collaborations; Communicable Diseases; Diabetes Mellitus; Disease; Drug Formulations; Dust; Educational workshop; Ethiopia; Flow Cytometry; Ghana; Hemoglobinopathies; Human; Human Genome; Immunomodulators; Institutes; International; Investigation; Laboratories; Laboratory Research; Leishmaniasis; Malaria; Mass Fragmentography; Medical; Medicine; Mentors; Microscopy; Minority Groups; Minority Health and Health Disparities International Research Training; Modeling; Morehouse School of Medicine; Nigeria; Patient Care; Pharmacogenomics; Physicians; Population; Prevention; Proteomics; Recruitment Activity; Research; Research Design; Research Training; Role; Sahara; Schistosomiasis; Scientist; Sickle Cell Anemia; Signal Transduction; Site; Students; Teaching Hospitals; Training; Underrepresented Students; Universities; Vector-transmitted infectious disease; Water; Work; base; diabetes management; functional genomics; health disparity; immunocytochemistry; improved; innovation; medical schools; meetings; precision medicine; programs; success; symposium

DESCRIPTION (provided by applicant): Howard University, partnering with scientists at Morehouse School of Medicine, and Research Scientists and Physicians in top research laboratories in Ethiopia, Ghana, and Nigeria will continue and initiate programs that offer practical and innovative international research training opportunities at foreign sites to undergraduate, medical, graduate and behavioral sciences students from underrepresented minority groups. Based on a record of success in research and training, students and mentors will return to the Pathobiology Institute, Addis Ababa University, University of Benin, University of Ghana-Korle bu Teaching Hospital where they will be engaged in research on water and blood-borne diseases and the study of vectors transmitting these diseases. Specifically investigations will be conducted on schistosomiasis, leishmaniasis and the utilization of natural products extracts in the prevention of bilharziasis, human schistosomiasis, and malaria. Further isolation, characterization and formulation of natural product extracts will be analyzed by GCMS, MALD-TOFF, chemical analysis, and effects on cell functions by flow cytometry, immunocytochemistry and microscopy in laboratories at foreign sites and at Howard University by collaboration. Infectious diseases studies will be further enhanced through collaboration at new sites including the Center for Leishmaniasis Research, and Gondar University. Research and training will continue at the Universities of Ghana and Benin, and at new sites where the emphasis will be on malaria, sickle cell anemia and hemoglobinopathies, and natural products medicine. A new site at the University of Ghana Medical School, Diabetes Clinic/National Diabetes Management and Research Centre, will provide training opportunities in pharmacogenomics research designed for improved patient care in the emergent era of personalized/precision medicine. The Universities of Ghana and Benin sites will employ bio-informatics, functional genomics, and proteomics in human models to study the role of immunomodulators and natural products extracts, apoptosis, and signaling factors in proposed human genome studies. In addition, water-borne, blood-borne, and air- (dust) borne diseases originating from the Sahara that affect populations in sub-Sahara Africa, and the Caribbean will be investigated. Each year for five years, 12 MHIRT Trainees recruited from U.S. universities and their U.S. and Foreign Mentors will spend 10 weeks working at foreign sites in Africa, and return to the U.S. disseminating research findings at national meetings, symposia and workshops.

描述（由申请人提供）：霍华德大学与莫尔豪斯医学院的科学家以及埃塞俄比亚、加纳和尼日利亚顶级研究实验室的研究科学家和医生合作，将继续启动项目，为来自代表性不足的少数群体的本科生、医学生、研究生和行为科学学生提供在国外的实用和创新的国际研究培训机会。基于研究和培训方面的成功记录，学生和导师将返回病理生物学研究所、亚的斯亚贝巴大学、贝宁大学、加纳大学科尔勒布教学医院，在那里从事水源和血源性疾病的研究以及传播这些疾病的媒介的研究。将针对血吸虫病、利什曼病以及利用天然产物提取物预防血吸虫病、人类血吸虫病和疟疾进行具体研究。天然产物提取物的进一步分离、表征和配方将通过 GCMS、MALD-TOFF、化学分析进行分析，并通过流式细胞术、免疫细胞化学和显微镜在国外实验室和霍华德大学的合作中对细胞功能的影响进行分析。通过利什曼病研究中心和贡德尔大学等新地点的合作，将进一步加强传染病研究。加纳和贝宁的大学以及新地点将继续进行研究和培训，重点是疟疾、镰状细胞性贫血和血红蛋白病以及天然产物医学。加纳大学医学院的糖尿病诊所/国家糖尿病管理和研究中心的新地点将提供药物基因组学研究的培训机会，旨在在个性化/精准医疗的新兴时代改善患者护理。加纳大学和贝宁大学将在人体模型中采用生物信息学、功能基因组学和蛋白质组学，研究免疫调节剂和天然产物提取物、细胞凋亡和信号因子在拟议的人类基因组研究中的作用。此外，还将调查源自撒哈拉沙漠、影响撒哈拉以南非洲和加勒比地区人口的水传播、血传播和空气（灰尘）传播疾病。五年内，每年从美国大学招募的 12 名 MHIRT 学员及其美国和外国导师将在非洲的外国地点工作 10 周，然后返回美国，在全国会议、专题讨论会和讲习班上传播研究成果。