HEALTH DISPARITIES RESEARCH THROUGH INTERNATIONAL EXCHANGE

描述(由申请人提供)：霍华德大学将与莫尔豪斯医学院的科学家以及埃塞俄比亚、加纳和尼日利亚顶尖研究实验室的研究科学家和医生合作，继续并启动项目，为来自少数族裔群体的本科生、医学、研究生和行为科学专业的学生提供在外国网站的实用和创新的国际研究培训机会。根据研究和培训的成功记录，学生和导师将回到亚的斯亚贝巴大学、贝宁大学、加纳大学科勒布教学医院的病理生物学研究所，在那里他们将从事水和血液传播疾病的研究以及传播这些疾病的媒介的研究。具体将调查血吸虫病、利什曼病以及天然产品提取物在预防血吸虫病、人类血吸虫病和疟疾中的利用情况。进一步的天然产品提取物的分离、表征和配方将通过GCMS、MALD-TOOFF、化学分析进行分析，并通过流式细胞仪、免疫细胞化学和显微镜在国外实验室和霍华德大学合作进行对细胞功能的影响。通过在利什曼病研究中心和贡达尔大学等新地点开展合作，传染病研究将得到进一步加强。加纳大学和贝宁大学以及将重点放在疟疾、镰状细胞性贫血和血红蛋白疾病以及天然产物药物的新地点将继续进行研究和培训。加纳大学医学院糖尿病诊所/国家糖尿病管理和研究中心的一个新网站将提供药物基因组学研究的培训机会，旨在改善个性化/精准医学新时代的患者护理。加纳大学和贝宁大学将在人体模型中应用生物信息学、功能基因组学和蛋白质组学，研究免疫调节剂和天然产物提取物、细胞凋亡和信号因子在拟议的人类基因组研究中的作用。此外，还将调查起源于撒哈拉沙漠、影响撒哈拉以南非洲和加勒比地区人口的水传播、血液传播和空气传播疾病。在五年的时间里，每年从美国大学招募的12名MHIRT学员及其美国和外国导师将在非洲的外国地点工作10周，然后返回美国，在全国会议、研讨会和研讨会上传播研究成果。

DESCRIPTION (provided by applicant): Howard University, partnering with scientists at Morehouse School of Medicine, and Research Scientists and Physicians in top research laboratories in Ethiopia, Ghana, and Nigeria will continue and initiate programs that offer practical and innovative international research training opportunities at foreign sites to undergraduate, medical, graduate and behavioral sciences students from underrepresented minority groups. Based on a record of success in research and training, students and mentors will return to the Pathobiology Institute, Addis Ababa University, University of Benin, University of Ghana-Korle bu Teaching Hospital where they will be engaged in research on water and blood-borne diseases and the study of vectors transmitting these diseases. Specifically investigations will be conducted on schistosomiasis, leishmaniasis and the utilization of natural products extracts in the prevention of bilharziasis, human schistosomiasis, and malaria. Further isolation, characterization and formulation of natural product extracts will be analyzed by GCMS, MALD-TOFF, chemical analysis, and effects on cell functions by flow cytometry, immunocytochemistry and microscopy in laboratories at foreign sites and at Howard University by collaboration. Infectious diseases studies will be further enhanced through collaboration at new sites including the Center for Leishmaniasis Research, and Gondar University. Research and training will continue at the Universities of Ghana and Benin, and at new sites where the emphasis will be on malaria, sickle cell anemia and hemoglobinopathies, and natural products medicine. A new site at the University of Ghana Medical School, Diabetes Clinic/National Diabetes Management and Research Centre, will provide training opportunities in pharmacogenomics research designed for improved patient care in the emergent era of personalized/precision medicine. The Universities of Ghana and Benin sites will employ bio-informatics, functional genomics, and proteomics in human models to study the role of immunomodulators and natural products extracts, apoptosis, and signaling factors in proposed human genome studies. In addition, water-borne, blood-borne, and air- (dust) borne diseases originating from the Sahara that affect populations in sub-Sahara Africa, and the Caribbean will be investigated. Each year for five years, 12 MHIRT Trainees recruited from U.S. universities and their U.S. and Foreign Mentors will spend 10 weeks working at foreign sites in Africa, and return to the U.S. disseminating research findings at national meetings, symposia and workshops.