Training Program in Microbial Pathogenesis

描述（由申请人提供）：本申请是犹他州大学2003年颁发的微生物致病机制培训项目的重新提交。该奖项的前五年成功地实现了在犹他州大学加强和促进微生物致病的目标，并为研究生和博士后研究员提供了新的培训机会。由于采取了一种综合办法，涉及不同部门和学科的实验室，受训人员之间进行了高水平的科学交流。在微生物学，免疫学和宿主反应，传染病/流行病学，艾滋病毒生物学，病原体传播的生态学和对病原体易感性的遗传学基础的教师，现在在培训补助金赞助的活动定期互动。该奖项的第一阶段导致：1）微生物发病机制和免疫学新课程的开发; 2）增加学员与微生物发病机制研讨会系列演讲者的互动; 3）形成一个新的微生物发病机制期刊俱乐部;和4）启动年度培训补助金务虚会，学员和外部专家演讲者的演讲。这些计划已经扩展到整个微生物发病机制社区。这次重新提交的计划更加重视监测学员的成功和项目活动，并为学员未来在微生物发病机制方面的职业生涯做好准备。这包括内部和外部审查，以及学员和导师的正式反馈。我们继续强调科学严谨的出版物的重要性，沿着众多的学术和职业建议的机会。培训生准备影响健康和研究的重要领域，包括新出现的传染病，宿主-病原体相互作用的分子遗传学，分子病毒学和流行病学，以及免疫反应参与宿主防御和感染的病理结果。离开培训补助金的AH受训人员目前在研究或学术界任职。基于第一个奖项的成功，我们要求继续支持3名博士前和3名博士后学员。 相关性：微生物发病机制作为一门学科涵盖了传染性病原体和人类或动物宿主之间的关键相互作用。了解这些相互作用的分子方面对于健康相关传染病研究的许多方面都很重要，包括分子发病机制，疫苗开发，治疗性治疗和流行病学。我们计划的学员广泛接触这些补品，并接受培训成为这一领域的复杂调查人员。

DESCRIPTION (provided by applicant): This application is a resubmission for renewal of the Training Program in Microbial Pathogenesis at the University of Utah awarded in 2003. The first five years of this award successfully accomplished the goals of enhancing and promoting Microbial Pathogenesis at the University of Utah and providing new training opportunities for graduate students and postdoctoral fellows. An integrated approach, involving laboratories from different departments and disciplines, has resulted in a high level of scientific exchange for the trainees. Faculty with foundations in microbiology, immunology and host responses, infectious disease/epidemiology, HIV biology, ecology of pathogen transmission, and genetics of susceptibility to pathogens, now interact on a regular basis at Training Grant-sponsored events. The first period of the award has resulted in: 1) the development of new courses in Microbial Pathogenesis and Immunology; 2) increased interaction of trainees with speakers at the Microbial Pathogenesis Seminar Series; 3) formation of a new journal club in Microbial Pathogenesis; and 4) the initiation of an Annual Training Grant Retreat with trainee presentations and those of outside expert speakers. These programs have extended to the Microbial Pathogenesis community as a whole. This resubmission provides greater emphasis on plans for monitoring trainee success and program activities, and in preparing trainees for future careers in Microbial Pathogenesis. This included internal and external reviews, and formal feedback from trainees and mentors. We continue to emphasize the importance of scientifically rigorous publications, along with numerous opportunities for academic and career advice. Trainees are prepared to impact important areas of health and research including emerging infectious diseases, molecular genetics of host-pathogen interactions, molecular virology and epidemiology, and involvement of immune responses in host defense and pathological outcomes of infection. AH trainees who have left the Training Grant currently hold positions in research or academics. Based on the success of the first award, we are requesting continued support for 3 pre-doctoral and 3 postdoctoral trainees. RELEVANCE: Microbial Pathogenesis as a discipline covers the critical interactions between infectious pathogens and the human or animal host. Understanding the molecular aspects of these interactions is important for many aspects of health related infectious disease research including molecular pathogenesis, vaccine development, therapeutic cures, and epidemiology. Trainees in our program have a broad exposure to these tonics and are trained as sophisticated investigators in this area.