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2/2 - Familial Early-Onset Suicide Attempt Biomarkers

2/2 - 家族性早发性自杀企图生物标志物

基本信息

批准号：
8967768
负责人：
Joseph John Mann
金额：
$ 51.22万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-18 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8967768
关键词：
Adult Children Age Amygdaloid structure Attention Autoreceptors Binding Biological Biological Assay Biological Markers Brain Brain Stem Clinical assessments Cognition Data Disease susceptibility Distress Dorsal Family history of Feeling suicidal Funding Hippocampus (Brain)Hydrocortisone Image Image Analysis Individual Lateral MRI Scans Major Depressive Disorder Measures Medial Memory Mental disorders Midbrain structure Mood Disorders New York Onset of illness Parents Pathway interactions Performance Pharmaceutical Preparations Phenotype Positron-Emission Tomography Prefrontal Cortex Prevention Preventive Intervention Protocols documentation Reactive depression Recording of previous events Recruitment Activity Research Design Risk Serotonin Severities Site Stress Tests Suicide Suicide attempt Task Performances Testing Trier Social Stress Test Universities Volunteer Group Work attentional bias base biological adaptation to stress cognitive testing comparison group data management depressed patient early onset endophenotype follow-up healthy volunteer high risk mood regulation offspring performance site proband public health relevance raphe nuclei resilience response single episode major depressive disorder statistics suicidal behavior suicidal patient suicide rate trait

项目摘要

DESCRIPTION (provided by applicant): The suicide rate in the USA is the same as 60 years ago. Better prevention needs more data on risk and resilience biomarkers. We seek to determine both resilience and vulnerability potential endophenotypes for suicide attempts in major depressive disorder (MDD). Both endophenotypes may aid estimation of risk and provide new targets for prevention intervention. The study design compares healthy volunteers (Group 1) with medication-free adult offspring of a parent with MDD and suicidal behavior who are through the age of risk and can thus be divided into a resilient group (Group 4), a group with a diathesis for MDD (Group 2) and one with diatheses for MDD and suicide attempts (Group 3). Comparison of Groups 2 and 3 indicates the diathesis for suicidal behavior. Comparison of Group 1 and 4 indicates the resilience phenotype. Comparison of Group 1 and Group 2 indicates the diathesis for MDD. This study is a new direction based on our almost complete longitudinal two-site follow-up study (PI, J. John Mann, MD, MH056390, Columbia University, NYC and PI, David Brent, MD, MH056612, UPMC, Pittsburgh) of 701 offspring of 334 probands with mood disorder entitled: "Familial Pathways to Early-Onset Suicide Attempts" that has sought to identify mechanisms by which suicidal behavior risk is transmitted from parent to offspring. Our findings on risk traits in the domains of cognition, mood regulation and stress responses, together with a new domain of brain PET imaging of the 5-HT1A autoreceptor that regulates serotonin release, will focus the search for resilience and vulnerability phenotypes. This study will involve the same two performance sites as the current funded application that ends January 2015. The teams have worked together for >15 years and both teams have conducted PET studies of depressed and suicidal patients. We will recruit eligible offspring from the old study and recruit new offspring as needed for the four groups. Both sites will perform clinical and cognitive assessments, stress tests and PET/MRI scans using identical protocols. The New York site will be the data management site including image analyses and statistics, and assay cortisols.