CSHL 2015 Telomeres & Telomerase Conference

 描述（由申请人提供）：冷泉港端粒和端粒酶实验室会议，2015年4月28日至5月2日。 端粒是保护真核生物染色体末端的特殊蛋白质-DNA复合物。在大多数真核生物中，端粒含有由端粒酶逆转录酶维持的短DNA重复序列。由于端粒酶抵消了伴随线性DNA复制的末端序列丢失，因此这种酶是长期细胞增殖所必需的。端粒动力学和端粒酶活化在人类癌症和细胞衰老中起着关键作用，这一领域的研究迅速发展。这一领域发展的另一个动力是认识到短端粒导致的临床综合征范围迅速增加。因此，端粒领域现在是一个高度多样化和动态的研究领域，代表了各种各样的研究兴趣（衰老，端粒综合征，干细胞，细胞周期，减数分裂，重组，复制等）。以及对癌症抑制、发展、进展、诊断和治疗的高度重视。虽然该领域的主要部分与小鼠和人类系统一起工作，但它也受益于从研究各种不同的模式生物（鸟类，青蛙，苍蝇，植物，线虫，原生动物，芽殖酵母，裂变酵母和其他真菌）中获得的见解。2009年诺贝尔医学/生理学奖授予伊丽莎白·布莱克本（Elizabeth Blackburn）、卡罗尔·格雷德（Carol Greider）和杰克·绍斯塔克（Jack Szostak），以表彰他们在发现端粒酶方面的开创性工作;本次会议的共同组织者蒂蒂娅·德·兰格（Titia de Lange）因其在端粒保护方面的工作获得了生命科学突破奖和盖尔奖，突出了端粒生物学基础研究的成功。 前八次冷泉港实验室关于端粒和端粒酶的会议对于汇集来自世界各地的不同研究人员至关重要，并导致了激烈的讨论和协同作用，这些讨论和协同作用受到了大多数未发表数据的刺激。由于CSHL端粒和端粒酶会议仍然是这个快速发展领域的科学家进行整体互动的唯一机会，因此这次会议是独特的，并且对该领域的未来至关重要。此外，CSHL会议的形式，几乎所有的演讲都是从提交的摘要中选择的，最大限度地为新的独立调查人员，博士后和研究生提供了在一个高度可见的场所展示他们工作的机会。这些会议都有一个国际研究小组的一致高出席率。在过去的会议上，讲台和海报展示在出版之前就介绍了该领域的重大发现。我们希望2015年会议也能得到同样踊跃的参加。

 DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase April 28 - May 2, 2015. Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. Since telomerase counteracts the terminal sequence loss that accompanies replication of linear DNA, this enzyme is required for long-term cellular proliferation. The field of telomere biology grew rapidly once it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. A further impetus to the growth of this field has been the recognition of a rapidly increasing range of clinical syndromes resulting from short telomeres. As a result, the telomere field is now a highly diverse and dynamic research area, representing a wide variety of research interests (aging, telomere syndromes, stem cells, cell cycle, meiosis, recombination, replication, etc.) as well as a strong emphasis on cancer suppression, development, progression, diagnosis and treatment. Although a major part of the field works with mouse and human systems, it also benefits from insights gained from study of a wide variety of different model organisms (birds, frogs, flies, plants, nematodes, protozoa, budding yeast, fission yeast, and other fungi). The success of basic research in telomere biology was highlighted by the awarding of the 2009 Nobel Prize in Medicine/Physiology to Elizabeth Blackburn, Carol Greider, and Jack Szostak for their pioneering work in the discovery of telomerase as well as the Breakthrough Prize in Life Sciences and the Gairdner award to the current meeting co-organizer Titia de Lange for her work on telomere protection. The previous eight Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase have been crucial in bringing together a diverse group of researchers from all parts of the world, and have resulted in vigorous discussion and synergistic interactions stimulated by the presentation of mostly unpublished data. Because the CSHL Telomeres and Telomerase conference remains the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is unique and of the utmost importance for the future of the field. Moreover, the format of CSHL meetings, for which nearly all talks are chosen from submitted abstracts, maximizes the opportunity for new independent investigators, postdocs and graduate students to present their work in a highly visible venue. These meetings have all had a uniformly high attendance rate from an international group of researchers. The podium and poster presentations at the past meetings presented the major discoveries in the field well before publication. We expect that the 2015 meeting will be equally well attended.