CSHL 2015 Telomeres & Telomerase Conference

 描述(申请人提供)：2015年4月28日至5月2日，冷泉港端粒和端粒酶实验室会议。端粒是一种特殊的蛋白质-DNA复合体，保护真核染色体的末端。在大多数真核生物中，端粒包含由端粒酶逆转录酶维持的短DNA重复序列。由于端粒酶抵消了伴随线性DNA复制的末端序列丢失，这种酶是细胞长期增殖所必需的。自从人们认识到端粒动力学和端粒酶激活在人类癌症和细胞衰老中起着关键作用后，端粒生物学领域迅速发展起来。这一领域发展的另一个推动力是人们认识到由于端粒过短而导致的临床症状范围迅速增加。因此，端粒领域现在是一个高度多样化和动态的研究领域，代表了广泛的研究兴趣(衰老、端粒综合征、干细胞、细胞周期、减数分裂、重组、复制等)。以及对癌症的抑制、发展、进展、诊断和治疗的高度重视。虽然该领域的主要部分与老鼠和人类系统一起工作，但它也受益于对各种不同模式生物(鸟类、青蛙、苍蝇、植物、线虫、原生动物、萌芽酵母、分裂酵母和其他真菌)的研究。2009年诺贝尔医学/生理学奖授予伊丽莎白·布莱克本、卡罗尔·格雷德和杰克·绍斯塔克，以表彰他们在发现端粒酶方面的开创性工作，并将生命科学突破奖和盖尔德纳奖授予本次会议的联合组织者蒂蒂娅·德兰格，以表彰她在端粒保护方面的工作，这突显了端粒生物学基础研究的成功。之前关于端粒和端粒酶的八次冷泉港实验室会议对于将来自世界各地的不同研究人员聚集在一起起到了至关重要的作用，并由于提出了大多数未公布的数据而导致了激烈的讨论和协同互动。由于CSHL端粒和端粒酶会议仍然是这一快速增长领域的科学家作为一个整体进行互动的唯一机会，因此这次会议是独一无二的，对该领域的未来至关重要。此外，CSHL会议的形式--几乎所有的演讲都是从提交的摘要中挑选出来的--最大限度地为新的独立调查人员、博士后和研究生提供了在一个非常显眼的场所介绍他们的工作的机会。所有这些会议都有一个国际研究小组一致的高出席率。在过去几次会议上的讲台和海报介绍在出版之前很久就介绍了该领域的主要发现。我们预计，2015年会议的出席人数也将同样多。

 DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase April 28 - May 2, 2015. Telomeres are specialized protein-DNA complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. Since telomerase counteracts the terminal sequence loss that accompanies replication of linear DNA, this enzyme is required for long-term cellular proliferation. The field of telomere biology grew rapidly once it was recognized that telomere dynamics and telomerase activation play a pivotal role in human cancer and in cellular senescence. A further impetus to the growth of this field has been the recognition of a rapidly increasing range of clinical syndromes resulting from short telomeres. As a result, the telomere field is now a highly diverse and dynamic research area, representing a wide variety of research interests (aging, telomere syndromes, stem cells, cell cycle, meiosis, recombination, replication, etc.) as well as a strong emphasis on cancer suppression, development, progression, diagnosis and treatment. Although a major part of the field works with mouse and human systems, it also benefits from insights gained from study of a wide variety of different model organisms (birds, frogs, flies, plants, nematodes, protozoa, budding yeast, fission yeast, and other fungi). The success of basic research in telomere biology was highlighted by the awarding of the 2009 Nobel Prize in Medicine/Physiology to Elizabeth Blackburn, Carol Greider, and Jack Szostak for their pioneering work in the discovery of telomerase as well as the Breakthrough Prize in Life Sciences and the Gairdner award to the current meeting co-organizer Titia de Lange for her work on telomere protection. The previous eight Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase have been crucial in bringing together a diverse group of researchers from all parts of the world, and have resulted in vigorous discussion and synergistic interactions stimulated by the presentation of mostly unpublished data. Because the CSHL Telomeres and Telomerase conference remains the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is unique and of the utmost importance for the future of the field. Moreover, the format of CSHL meetings, for which nearly all talks are chosen from submitted abstracts, maximizes the opportunity for new independent investigators, postdocs and graduate students to present their work in a highly visible venue. These meetings have all had a uniformly high attendance rate from an international group of researchers. The podium and poster presentations at the past meetings presented the major discoveries in the field well before publication. We expect that the 2015 meeting will be equally well attended.