Bioinformatics and Information Technologies

生物信息学和信息技术

• 批准号: 8819504
• 负责人: DOUGLAS D RICHMAN
• 金额: $ 2.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8819504
• 关键词: Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Age; Applications Grants; Area; Big Data; Bioinformatics; Biological Assay; Biomedical Technology; Biometry; Car Phone; Case Report Form; Clinical; Cohort Studies; Communities; Complex; Computational Biology; Computational Technique; Computer Analysis; Computer software; Consultations; Custom; Data; Data Analyses; Data Collection; Data Set; Development; Drug resistance; Engineering; Enrollment; Epidemiology; Epigenetic Process; Epitopes; Flow Cytometry; Future; Genetic; Genomics; Grant; HIV; HIV-1; Housing; Immune; Impairment; Informatics; Information Technology; Instruction; Internet; Intervention; Laboratories; Machine Learning; Management Audit; Measures; Mentorship; Metagenomics; Methods; Mission; Modeling; Molecular; Neurologic; New York; Online Systems; Outcome; Pattern; Phenotype; Phylogenetic Analysis; Positioning Attribute; Process; Public Health; Publishing; Recording of previous events; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Sampling; Schedule; Secure; Seminal fluid; Sequence Analysis; Services; Solutions; Specimen; Structure; System; Techniques; Testing; Time; Training; Viral; Viral Genome; base; biomedical facility; cohort; computer infrastructure; cost; data management; data mining; design; discount; field survey; flexibility; innovation; interest; member; metabolomics; network models; neutralizing antibody; next generation sequencing; programs; public health intervention; social; software development; tool; transmission process; virus genetics; web services; web site; working group

PROJECT SUMMARY (See instructions): Core L - Scientific inquiry and public health are being fundamentally changed by immense volumes of complex data, and modern computational techniques that are able to mine these data for pattern discovery and inference. The field of HIV research is no exception, and many innovative discoveries have been facilitated or validated by sophisticated modeling and data analyses. Traditional biostatistics services are neither designed to handle gigantic volumes of complex data, nor are these new data types (e.g., next generation sequencing data) a natural fit for current computational biology and informatics applications. The purpose of the Bioinformatics and Information Technologies (BIT) is to handle CFAR investigator demand for storing, managing, analyzing, interpreting, and disseminating large and complex data sets, especially those containing viral and host molecular sequences. Based on ongoing and anticipated future needs of CFAR members, in the next five years, the BIT Core is structured as three interlinked units that will: (1) provide bioinformatics support for CFAR researchers by leveraging world-class expertise in bioinformatics and computational biology available at UCSD to offer a comprehensive spectrum of services and consultations related to computational analyses of data collected by CFAR investigators; (2) supply content management systems, web services for biomedical data, and computational infrastructure; and (3) provide training in bioinformatics and information technology. The BIT Core is uniquely positioned to provide these innovative services to CFAR members by drawing upon cutting edge in-house methodological research, modern sequencing and biomedical technologies offered by other CFAR Cores (e.g. GS, PEP, Flow Cytometry Cores), and professional software development and support expertise of its programming team. The CFAR External Advisory Committee reviewed our Center in February, 2012 and noted the following about the BIT Core in their final report: "The BIT Core is likely to set the standard for how CFARs handle next generation sequencing analysis, cohort data management and provide web presence."

项目摘要（参见说明）：核心 L - 大量复杂数据以及能够挖掘这些数据以进行模式发现和推理的现代计算技术正在从根本上改变科学探究和公共卫生。 HIV 研究领域也不例外，许多创新发现都是通过复杂的建模和数据分析得到促进或验证的。传统的生物统计服务既不是为处理大量复杂数据而设计的，这些新数据类型（例如下一代测序数据）也不是当前计算生物学和信息学应用的自然选择。生物信息学和信息技术 (BIT) 的目的是满足 CFAR 研究人员对存储、管理、分析、解释和传播大型复杂数据集（尤其是包含病毒和宿主分子序列的数据集）的需求。根据 CFAR 成员持续和预期的未来需求，在未来五年内，BIT 核心由三个相互关联的单元组成，这些单元将：（1）利用 UCSD 提供的世界一流的生物信息学和计算生物学专业知识，为 CFAR 研究人员提供生物信息学支持，提供与 CFAR 研究人员收集的数据计算分析相关的全面服务和咨询； (2) 提供内容管理系统、生物医学数据网络服务和计算基础设施； (3) 提供生物信息学和信息技术培训。 BIT 核心具有独特的优势，通过利用其他 CFAR 核心（例如 GS、PEP、流式细胞术核心）提供的尖端内部方法学研究、现代测序和生物医学技术，以及其编程团队的专业软件开发和支持专业知识，为 CFAR 成员提供这些创新服务。 CFAR 外部咨询委员会于 2012 年 2 月审查了我们的中心，并在其最终报告中指出了有关 BIT 核心的以下内容：“BIT 核心可能会为 CFAR 如何处理问题设定标准。 下一代测序分析、队列数据管理并提供网络展示。”