Electron Microscopy Laboratory

电子显微镜实验室

• 批准号: 8008867
• 负责人: LARRY ARTHUR
• 金额: $ 88.53万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8008867
• 关键词: Animals; Biological; Cells; Collaborations; Confocal Microscopy; Development; Electron Microscopy; Image Analysis; Individual; Kinetics; Laboratories; Molecular; National Cancer Institute; Nuclear; Pathway interactions; Principal Investigator; Proteins; Quantitative Microscopy; Reporting; Research; Resources; Role; STAT3 gene; Sampling; Site Visit; Solid Neoplasm; Tissues; Translational Research; carcinogenesis; molecular scale

The Image Analysis Laboratory (IAL) at the National Cancer Institute - Frederick focuses research on quantitative microscopy for understanding carcinogenesis in solid tumors by analyzing the kinetics of molecular pathways in individual cells while cells remain in their tissue context. Research is done mostly by collaborations with multiple NCI principal investigators, with special emphasis on the cytoplasmic and nuclear roles of the protein STAT3. Technical developments also aim to provide an integrated resource for analysis of biological samples across multiple scales from molecular to the animal level, thus providing a seamless, bidirectional transition between basic and translational research. IAL received an outstanding site visit review in the early summer. IAL is administratively divided into two parts: confocal microscopy (CM) and electron microscopy (EM); therefore, each part is reported separately.

图像分析实验室（IAL）在国家癌症研究所-弗雷德里克专注于定量显微镜的研究，通过分析单个细胞中的分子通路的动力学，同时细胞保持在其组织环境中，以了解实体瘤的致癌作用。研究主要是通过与多个NCI主要研究人员的合作完成的，特别强调蛋白质STAT 3的细胞质和细胞核作用。技术发展还旨在为从分子到动物水平的多个尺度的生物样品分析提供综合资源，从而在基础研究和转化研究之间提供无缝的双向过渡。IAL在初夏收到了出色的现场访问审查。IAL在行政上分为两个部分：共聚焦显微镜（CM）和电子显微镜（EM）;因此，每个部分单独报告。