Electron Microscopy Laboratory

弗雷德里克国家癌症研究所的图像分析实验室(IAL)专注于定量显微镜的研究，通过分析单个细胞中分子通路的动力学，而细胞保持在其组织环境中，以了解实体肿瘤的致癌机理。研究主要是通过与多个NCI主要研究人员的合作完成的，特别强调蛋白质STAT3的细胞质和核角色。技术发展还旨在为从分子到动物层面的多个尺度的生物样本分析提供综合资源，从而在基础研究和翻译研究之间提供无缝、双向的过渡。在初夏，IAL收到了一份出色的实地考察报告。免疫组化分为两部分：共聚焦显微镜(CM)和电子显微镜(EM)；因此，每一部分都是单独报道的。

The Image Analysis Laboratory (IAL) at the National Cancer Institute - Frederick focuses research on quantitative microscopy for understanding carcinogenesis in solid tumors by analyzing the kinetics of molecular pathways in individual cells while cells remain in their tissue context. Research is done mostly by collaborations with multiple NCI principal investigators, with special emphasis on the cytoplasmic and nuclear roles of the protein STAT3. Technical developments also aim to provide an integrated resource for analysis of biological samples across multiple scales from molecular to the animal level, thus providing a seamless, bidirectional transition between basic and translational research. IAL received an outstanding site visit review in the early summer. IAL is administratively divided into two parts: confocal microscopy (CM) and electron microscopy (EM); therefore, each part is reported separately.