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Membrane Protein Polyhedral Nanoparticles for High Resolution Structure/Function Studies

Membrane Protein Polyhedral Nanoparticles for High Resolution Structure/Function Studies
用于高分辨率结构/功能研究的膜蛋白多面体纳米颗粒
批准号：
8863303
负责人：
Michael H. B. Stowell
金额：
$30.33万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
项目状态：
已结题
起止时间：
2015-09-10 至 2017-08-31
来源：
https://reporter.nih.gov/project-details/8863303
关键词：
Adrenergic ReceptorBacteriorhodopsinsBiologicalCapsidChloroplastsCholineComplexCryoelectron MicroscopyCrystallographyData SetDetergentsDrug PrescriptionsDyesElectron MicroscopeElectron MicroscopyElectronsEnvironmentFreezingG Protein-Coupled Receptor GenesGated Ion ChannelHarvestHealthIonsLigandsLightLipidsMeasuresMembraneMembrane LipidsMembrane PotentialsMembrane ProteinsMethodsMicrofluidic MicrochipsMicrofluidicsMolecular ConformationPharmaceutical PreparationsPrincipal InvestigatorProblem SolvingProtein AnalysisProteinsReportingResolutionRoleSpecimenStructureSurfaceTestingTubeVesicleVirionVirusWorkbeta-2 Adrenergic Receptorsdesigndetectorinsightnanometernanoparticlenovel strategiesparticleprogramsprotein structureproteoliposomesreceptorscreeningself assemblysignal processingstemtool

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英文摘要
 DESCRIPTION (provided by applicant): This proposal aims to study the structure and function of membrane proteins using a novel approach that combines a microfluidic membrane self-assembling method with high throughput electron microscopy single particle analysis. We will leverage our previous work to realize a systematic approach to structural analysis of membrane proteins in a biological membrane. The overall objective of this proposal will be determining the structures of several membrane proteins both in the absence and presence of ligands and transmembrane gradients that alter the activity of the membrane protein. 0925-0001/0002 (Rev. 08/12) Page Continuation Format Page
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Membrane Protein Polyhedral Nanoparticles for High Resolution Structure/Function Studies
  • 批准号：
    9136219
  • 项目类别：
  • 资助金额：
    $30.42万
  • 财政年份：
    2015
  • 负责人：
    Michael H. B. Stowell
  • 依托单位：
    UNIVERSITY OF COLORADO
ION CHANNEL STRUCTURE AND MECHANISM
  • 批准号：
    8362549
  • 项目类别：
  • 资助金额：
    $2.13万
  • 财政年份：
    2011
  • 负责人：
    Michael H. B. Stowell
  • 依托单位：
    UNIVERSITY OF COLORADO
SYNAPTIC ARCHITECTURE, DYNAMICS AND MECHANISM
  • 批准号：
    8362548
  • 项目类别：
  • 资助金额：
    $2.13万
  • 财政年份：
    2011
  • 负责人：
    Michael H. B. Stowell
  • 依托单位：
    UNIVERSITY OF COLORADO
ION CHANNEL STRUCTURE AND MECHANISM
  • 批准号：
    8170847
  • 项目类别：
  • 资助金额：
    $3.74万
  • 财政年份：
    2010
  • 负责人：
    Michael H. B. Stowell
  • 依托单位：
    UNIVERSITY OF COLORADO
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