Developmental Research Program

发展研究计划

• 批准号: 8930237
• 负责人: ALEXANDER KEITH STEWART
• 金额: $ 11.88万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8930237
• 关键词: Area; Basic Science; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Development; Discipline; Fostering; Foundations; Funding; Future; Goals; Grant; Incidence; Laboratory Study; Mayo Clinic Cancer Center; Monitor; Multiple Myeloma; Outcome; Patients; Pilot Projects; Psychological Techniques; Quality of life; Recommendation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scientist; Seeds; Testing; Translating; Translational Research; United States National Institutes of Health; base; improved; innovation; mortality; novel; programs; sound; translational study; tumor

ABSTRACT: The goal of the Developmental Research Program in the Mayo Clinic SPORE in Multiple Myeloma is to support innovative, scientifically sound projects that investigate any area pertaining to translational myeloma research. Funding from this program will stimulate developmental research that incorporates techniques and theoretical approaches that may not have been previously utilized in myeloma research. In so doing it provides a mechanism by which the SPORE can increase the number of scientists and clinical investigators who are committed to translational myeloma research. The Developmental Research Program will encourage the development of suitable projects, coordinate project review and selection, make funding recommendations to the Executive Committee, and monitor research progress. We have requested $130,000 annually ($80,000 per year from the SPORE funds augmented by $50,000 per year in matching funds from the Mayo Clinic Cancer Center) for the Developmental Research Program. We aim to provide research support to two to three projects per year for one year with a second year of support possible based on exceptional progress towards the stated aims of the project. The long term goal is to translate the findings generated by developmental projects into a reduction in the incidence and mortality rates of myeloma. Without the funding, infrastructure, and expertise of the SPORE projects and investigators, it will be unlikely that innovative developmental research projects of the kind we envision can be brought to fruition. Specifically, the primary goals of the Developmental Research Program are to: (1) encourage innovative translational studies that are promising and have the potential to improve outcome in myeloma and mature into independently funded projects; (2) foster extensive collaboration between basic science and clinical disciplines in translational research in myeloma in the context of the myeloma SPORE program; (3) encourage investigators to apply their research findings in other tumor types to translational research in myeloma and; (4)generate new hypotheses that can be tested and provide the foundation for future large-scale research projects or clinical trials in order to reduce myeloma incidence and mortality rates.

摘要： 梅奥临床多发性骨髓瘤孢子发育研究计划的目标是 支持创新的、科学合理的项目，这些项目调查与翻译有关的任何领域 骨髓瘤研究。来自该项目的资金将刺激包括以下内容的发展研究 以前可能没有在骨髓瘤研究中使用的技术和理论方法。在……里面 因此，它提供了一种机制，通过这种机制，孢子可以增加科学家和临床人员的数量 致力于翻译骨髓瘤研究的研究人员。发展性研究 计划将鼓励开发合适的项目，协调项目审查和选择， 向执行委员会提出资金建议，并监督研究进展。我们有 每年申请130,000美元(孢子基金每年80,000美元，#年每年增加50,000美元 来自梅奥临床癌症中心的等额资金)用于发展研究计划。我们的目标是 每年为两到三个项目提供研究支持，为期一年，第二年提供支持 基于在实现项目所述目标方面取得的特殊进展，这是可能的。长期目标是 将发展项目产生的结果转化为发病率和死亡率的降低 骨髓瘤的发生率。如果没有孢子项目的资金、基础设施和专业知识， 调查人员说，我们设想的那种创新发展研究项目不太可能 结出硕果。具体地说，发展研究计划的主要目标是：(1) 鼓励有前景并有潜力改善成果的创新性翻译研究 骨髓瘤和成熟成为独立资助的项目；(2)促进基础设施之间的广泛合作 骨髓瘤孢子背景下骨髓瘤的翻译研究中的科学和临床学科 计划；(3)鼓励研究人员将他们在其他肿瘤类型上的研究成果应用于翻译 对骨髓瘤的研究；(4)产生可以检验的新假说，并为 未来的大规模研究项目或临床试验，以降低骨髓瘤的发病率和死亡率 费率。