ES Cell & Transgenics

基因工程小鼠模型对于科赫研究所成员的研究计划至关重要。他们 用于探测癌基因在细胞和发育生物学中的作用，研究 肿瘤发展、进展和转移，评估药物反应和耐药性，并测试新的 用于肿瘤检测和药物递送的策略和装置。ES细胞和转基因核心是一个 机构共享资源，为科赫研究所的研究人员提供咨询意见，技术 支持和/或培训工程细胞和小鼠模型的生产。在本期间， 这一核心的能力得到了进一步扩大和加强。这包括进入一个更大的， 定制设计的空间在新的科赫研究所大楼，增加了新的服务和重组， 工作人员支持新手用户并提供项目定制服务。值得注意的是，在同一时期， 中心成员的ES细胞和转基因核心从29%增加到51%，包括研究人员 四个方案。因此，这种共享资源对于科赫研究所使命的成功至关重要。 在即将到来的时期，ES细胞和转基因核心将继续提供广泛的最先进的 支持中心成员的研究计划。尽管服务业大幅扩张， 第44年要求的CCSG预算比要求和建议的低13%， 第39年的预算。

Genetically engineered mouse models are critical for the research programs of Koch Institute Members. They are used to probe the role of cancer genes in cell and developmental biology, investigate the mechanisms of tumor development, progression and metastasis, evaluate drug response and resistance, and test novel strategies and devices for tumor detection and drug delivery. The ES Cell & Transgenics Core is an Institutional Shared Resource that provides Koch Institute investigators with consultative advice, technical support and/or training in the production of engineered cells and mouse models. In the current period, the capabilities of this Core have been further expanded and enhanced. This includes moving into a larger, custom-designed space in the new Koch Institute building, the addition of new services and a reorganization of the staff to support novice users and provide project-customized services. Notably, in the same period, usage of the ES Cell & Transgenics Core by Center Members increased from 29% to 51%, including investigators from all four programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, the ES Cell & Transgenics Core will continue to offer a wide range of state-of-the-art services to support the research programs of Center Members. In spite of the significant expansion of services and usage, the requested CCSG budget for Year 44 is 13% lower than the requested and recommended budget in Year 39.