2013 Infectious Diseases in Africa: Measurement of Immune Responses

描述（由申请人提供）：非洲大陆巨大的传染病负担主要由艾滋病毒、结核病和疟疾组成。仅这三种疾病就在大多数非洲国家所有年龄组造成社会和经济不稳定。到2010年中期，撒哈拉以南非洲有2290万艾滋病毒感染者，约占所有艾滋病毒感染者的68%（艾滋病规划署2011年全球报告）。尽管非洲结核病病例的绝对数量自2006年以来一直在下降，但根据世卫组织关于全球结核病控制的最新报告（2011年），2012年非洲有880万例结核病病例。2010年，疟疾造成约655，000人死亡，主要是非洲儿童（世卫组织概况介绍，2012年），据估计，疟疾造成生产力下降，导致一些非洲国家每年1.3%的增长损失。非洲人口中的这一令人难以置信的疾病负担正在对社会的各个方面造成破坏，特别是对大多数非洲国家的经济造成破坏。虽然在受影响最严重的国家内有许多措施来应对艾滋病毒、结核病和疟疾造成的疾病负担，但在培训当地科学家掌握一些有助于国内防治工作的方法方面仍然存在空白。 research.在这笔赠款中，我们认为，青年科学家的培训应沿着实施现场物理基础设施，如实验室。重要的是，国内科学家有机会获得科学知识和培训，以寻求这些传染病的免疫保护的相关性。通过组织题为“非洲传染病：免疫反应的测量”的专题讨论会（开普敦大学，南非开普敦，2013- 2015年5月），我们的目标是：1）继续提供结核病、艾滋病毒和疟疾以及免疫学领域的尖端知识2）在非洲大陆培养新的科学领导。

DESCRIPTION (provided by applicant): The huge communicable disease burden on the African continent is largely made up of HIV, Tuberculosis and Malaria. The trio of diseases alone is creating societal and economic instability in most African countries within all age groups. By mid-2010, the 22.9 million people living with HIV in sub-Saharan Africa made up approximately 68% of all people living with HIV (UNAIDS 2011 Global Report). Although the absolute number of TB cases in Africa has been falling since 2006, according to the latest WHO report on Global TB Control (2011), Africa had 8.8 million incident cases of TB in 2012. In 2010, malaria caused an estimated 655,000 deaths mostly among African children (WHO factsheet 2012) and it has been estimated that malaria is responsible for loss in productivity that results i a 1.3% growth penalty per year in some African countries. This incredible burden of diseases amongst African populations is causing devastation in all facets of society, most notably in the economies of most African countries. Although there are many measures in place to tackle the disease burden from HIV, TB and Malaria within countries worst affected, there remains a void in terms of training local scientists in some of the methodologies that would facilitate in-country research. In this grant, we believe that training of young scientists should be conducted along with the implementation of in situ physical infrastructures, such as laboratories. It is important that in-country scientists have access to scientific knowledge and training to seek correlates of immune protection for these infectious diseases. By organizing this cycle of symposia, entitled: "Infectious Diseases in Africa: Measurement of Immune Response" (University of Cape Town, Cape Town, South Africa, May 2013- 2015), our objectives are: 1) To continue to provide cutting-edge knowledge in the fields of TB, HIV and malaria and immunology 2) To foster new scientific leadership on the African Continent.