Pre-doctoral Training Program in Integrative Vascular Biology

描述（申请人提供）：心血管疾病的发病机制十分复杂。因此，我们建议通过博士前培训期间开始的多学科合作，培养未来的血管生物学家能够实施结合“细胞”、“整个动物”和“人类”系统的综合方法。跨学科预科 北卡罗来纳大学综合血管生物学（IVB）博士培养项目成立于2002年，有效地团结了从事血管生物学广泛学科工作的研究生。 IVB 计划的成功清楚地证明了以下事实：42 名学员中的 18 人在接受培训期间获得了个人奖学金，并且完成博士学位的 27 名过去学员中的 22 人正在学术环境中继续研究或成为医学院的住院医师/学生。该计划的目标（1）将血管生物学相关广泛研究领域的研究生联系起来，并培养他们的沟通和协作技能； （二）通过合作促进合作 不同部门的导师，从而整合与学员论文研究相关的广泛知识基础和技能。此续签申请需要资金来继续我们的 IVB 计划，每年为 12 名学员提供支持，每人最多三年。此次更新的一个新方法是识别来自少数族裔背景的优秀学生，并在第一年引导他们对血管生物学的兴趣；其中一个实习生职位将被专门指定来支持该研究员。其他学员将从北卡罗来纳大学已就读的院系研究生课程中挑选，并在第一年或第二年末选择血管生物学相关领域的论文项目/导师。为了鼓励多学科方法，我们要求每个学员除了传统的主要导师之外还有一位合作顾问。 IVB 项目由全校分子生物学和生物技术项目管理。病理学和检验医学教授 Nobuyo Maeda 博士担任主任，博士。凯瑟琳·卡伦，副教授。细胞和分子生理学教授以及生物化学和生物物理学教授兼主席 Leslie Parise 担任副主任。主要导师是来自北卡罗来纳大学 4 个学院和 1 个学院 13 个系的教职人员，他们都坚定地致力于通过血管生物学相关研究进行博士前培训。为了形成一个供受训者选择合作的补充教师队伍，主要培训教师由北卡罗来纳大学的临床教师和研究人员加入，他们维护着活跃的实验室，主要由博士后研究员组成。麦卡利斯特心脏研究所还为 IVB 社区提供支持，该研究所提供一系列研讨会和研究血管生物学的核心设施。北卡罗来纳大学 IVB 项目凭借其在血管生物学研究领域的悠久历史和广度、强大的研究团队以及动物模型研究实力，为博士前学生的多学科培训提供了理想的环境。 （摘要完）

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Accordingly, we propose to train future vascular biologists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems through multidisciplinary collaborations that begin during pre-doctoral training. The interdisciplinary pre doctoral training program in Integrative Vascular Biology (IVB) at the University of North Carolina was established in 2002 and has effectively united graduate students who are working in broad disciplines of vascular biology. The success of the IVB Program is clearly demonstrated by the fact that 18 of the 42 trainees received individual fellowships while they were/are in training, and that 22 of 27 past trainees who completed their PhDs are continuing research in academic settings or are residents/students at Medical Schools. The program aims (1) To connect graduate students in broad areas of research related to vascular biology and to cultivate their communication and collaboration skills; (2) To facilitate collaborations through co mentors in different Departments, and thereby integrate a broad knowledge base and skill set relevant to the trainee's thesis research. This renewal application requests funding to continue our IVB Program with support for 12 trainees per year, each up to three years. A new approach in this renewal is to identify outstanding students from under-represented minority backgrounds and guide their vascular biology interest during their first year; one of the trainee positions wil be specifically assigned to support this Fellow. Other trainees will be selected among those who are already in departmental graduate programs at UNC and have chosen thesis projects/mentors in areas related to vascular biology at the end of their first or second year. To encourage a multi-disciplinary approach, we require each trainee to have a collaborating advisor(s) in addition to their conventional primary mentor. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Prof. of Pathology and Laboratory Medicine, is the Director, and Drs. Kathleen Caron, Assoc. Prof. of Cell and Molecular Physiology, and Leslie Parise, Prof. and Chair of Biochemistry and Biophysics, are the Associate Directors. The primary mentors are faculty members at UNC from 13 Departments in four Schools and one College, all of which have a strong commitment to predoctoral training through vascular biology-related research. To form a body of complementing faculty with whom the trainees can choose to collaborate, the primary training faculty are joined by clinical faculty and investigators at UNC who maintain active laboratories staffed primarily with postdoctoral fellows. Support for the IVB community is also provided through the McAlister Heart Institute which offers a seminar series and Core facilities to study vascular biology. With its outstanding history and breadth in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an ideal environment for the multidisciplinary training of pre-doctoral students. (End of Abstract)