Cell Biology of Megakaryocytes & Platelets GRC & GRS /Bridging the Divide Between Megakaryocytes and Platelets-

 描述(申请人提供)：在防止组织损伤部位失血过多方面，血小板起着至关重要的作用。它们是由骨髓中的巨核细胞形成的，在静息状态下在血液中循环，但在血管系统受损时会经历“爆炸性”激活，支持血管堵塞的形成。与血小板数量减少相关的情况可能会导致大量出血。血小板在中风和心肌梗死中起着基础性作用，并有助于癌症的转移扩散。戈登巨核细胞和血小板细胞生物学研究会议(GRC)是专注于血小板及其前体细胞--巨核细胞生物学的领先科学会议。这将是第六次两年一度的会议，将目标和兴趣互补的两组科学家聚集在一起。会议主题将包括血小板在生物学中的新角色，包括免疫、肿瘤转移和淋巴发育。识别调节MK发育和血小板激活的新信号通路也将是一个关键主题，包括最初的专注于膜生物学的会议。体外培养血小板的新机制以及可视化MK和血小板生物学的创新方法也将受到关注。会议还将报告在调节循环血小板数量方面的最新发现。此外，还有一整节课专门讨论 热门话题陈述，精选表格提交摘要。计划中的会议有几个创新方面，包括1.一个题为血液药物：在体外制造血小板，提供机会了解和讨论新的巨核细胞和血小板生物学如何改变输血行业的新想法；2.会议将结合MK和血小板的开发和功能，从而迫使两个兴趣相投的观众联合起来，进一步增加思想交流；3.在一个名为：巨核细胞和血小板破裂的新会议中说明了床边潜力，并进行了讨论，例如关于低血小板计数的新治疗选择；4.首次列入题为：血小板作为瑞士军刀的会议，为了解和讨论血小板在其他领域的新作用提供了机会。为2015年会议保留戈登研究研讨会(GRS)是一个关键组成部分。这个场地鼓励有前途的受训者更明显地参与该计划，并可能鼓励他们继续并在MK和血小板生物学领域发展自己的事业。受训者提交的摘要将由评审团评分，并被选为口头报告，其中一些也将在GRC的热门话题下发表。与调查人员的公开讨论将提供与学术界和制药公司职业相关的指导。GRS/GRC于2015年4月18日至19日和19日至24日在意大利卢卡(巴尔加)的文艺复兴托斯卡纳II Ciocco度假村举行。

 DESCRIPTION (provided by applicant): Blood platelets play a critical role in the prevention of excessive blood loss at sites of tissue injury. They are formed from megakaryocytes in the bone marrow and circulate in the blood in a resting state, but undergo 'explosive' activation upon damage to the vasculature, supporting formation of a vascular plug. Conditions associated with a reduction in platelet number can lead to excessive bleeding. Platelets play a fundamental role in stroke and myocardial infarction, and contribute to the metastatic spread of cancer. The Gordon Research Conference (GRC) on the Cell Biology of Megakaryocytes and Platelets is the leading scientific meeting focused on the biology of platelets and their precursor cells, megakaryocytes. This will be the 6th biennial meeting that brings together two groups of scientists with complimentary goals and interests. Meeting topics will include emerging roles for platelets in biology, including immunity, tumor metastasis, and lymphatic development. Identification of novel signaling pathways that regulate MK development and platelet activation will also be a key theme, including an original session focused on membrane biology. Novel mechanisms for growing platelets in vitro as well as innovative ways to visualize MK and platelet biology will also come under the spotlight. The conference will also report on the latest findings in the regulation of circulating platelet numbers. In addition, there is a whole session devoted to presentations of Hot Topics, selected form submitted abstracts. There are several innovative aspects to the planned meeting, including 1. A session titled Blood Pharming: Making platelets in vitro, providing opportunities to learn about, and discuss new ideas about how novel megakaryocyte and platelet biology may transform the transfusion industry; 2. The sessions will combine both MK and platelet development and function, thus, forcing a union of two audiences with overlapping interests, further increasing exchange of ideas; 3. The bench to bedside potential is illustrated in a new session titled: Megakaryocytes and platelets breaking bad, and talks, such as on novel therapeutic options for low platelet counts; and 4. Inclusion, for the firs time, of a session titled: Platelets as the Swiss Army Knives of the Blood provides opportunities to learn about, and discuss new roles for platelets in other fields. The retention of the Gordon Research Seminar (GRS) for the 2015 meeting is a critical component. This venue encourages promising trainees to participate more visibly in the program and possibly be encouraged to continue and develop a career in MK and platelet biology. Abstracts submitted by trainees will be scored by a panel, and selected for oral presentations, of which some will also present under Hot Topics in the GRC. Open discussions with investigators will provide mentoring related to careers in academia and in pharmaceutical companies. The GRS/GRC take place from April 18-19th and 19-24th, 2015, at the Renaissance Tuscany II Ciocco Resort, Lucca (Barga), Italy.