Breast and Ovarian Cancer Program (Project-007)

摘要：乳腺癌和卵巢癌计划(BOCP) 乳腺癌和卵巢癌计划(BOCP)的使命，一项新设立的计划正在提出 在这次UPCI癌症中心的资助续期，是为了降低女性癌症的发病率和死亡率 重点放在乳腺癌和卵巢恶性肿瘤上。这一使命是通过发展和实现 促进乳腺癌和卵巢癌的基础、转译和临床研究，旨在转译 改善病人护理的新发现。BOCP有四个主要研究主题：1)基础癌症 生物学，2)诊断和预后标记物，3)预防，4)分子治疗。《BOCP》 具体目标是：1)研究癌症发生和发展的机制，2)识别和验证 新的诊断和预后标记物，3)检查肿瘤演变和异质性在 进展和对治疗的反应，4)发现转移的表型和基因依赖关系 5)将生物学知识转化为个性化的预防和治疗。BOCP已经 代表匹兹堡大学12个学术部门和3个学院的42名成员。基于 对2010年1月至2014年4月历史数据的回顾分析，BOCP成员撰写或联合- 撰写了517篇与癌症有关的出版物，其中31%来自方案内，30%来自方案间 程序性协作。大约54%的论文代表与外部合作 调查人员。BOCP的研究得到了NCI卓越研究专业计划的支持 (孢子)在卵巢癌与罗斯威尔公园癌症研究所(RPCI)共享，以及个人联邦 赠款、基金会奖和慈善事业。BOCP成员目前每年可获得总计820万美元 直接资助，包括来自NCI的260万美元和其他同行审查赠款支持的210万美元。一位高度 合作和互动小组，BOCP成员定期在工作进展会议上开会，日记 俱乐部，还有每年一度的静修。此外，BOCP还与其他项目建立了关系，以加强 威斯康星大学乳腺癌和卵巢癌研究的多学科性质。UPCI支持，包括临床 协议和数据管理及共享资源，特别是动物设施、生物统计设施、 癌症生物信息学服务，癌症基因组学设施，癌症药代动力学和药效学 设备，癌症蛋白质组设备，细胞和组织成像设备，化学生物学设备，细胞计数 设施，免疫监测和细胞产品实验室，活体成像设施，调查性 药物服务、组织和研究病理学服务促进和加强BOCP研究。

Abstract: Breast and Ovarian Cancer Program (BOCP) The mission of the Breast and Ovarian Cancer Program (BOCP), a newly established Program being proposed in this UPCI Cancer Center Support Grant renewal, is to reduce the incidence and death from women's cancer with a focus on breast and ovarian malignancies. This mission is achieved through the development and fostering of basic, translational, and clinical research in breast and ovarian cancer and aimed at translating novel discoveries into improved patient care. The BOCP has four main research themes: 1) basic cancer biology, 2) diagnostic and prognostic markers, 3) prevention, and 4) molecular therapeutics. The BOCP specific aims are to: 1) investigate mechanisms of cancer initiation and progression, 2) identify and validate new diagnostic and prognostic markers, 3) examine the role of tumor evolution and heterogeneity in progression and response to therapy, 4) discover the phenotypic and genotypic dependencies of metastatic cancer, and 5) translate knowledge of the biology into personalized prevention and treatment. The BOCP has 42 members representing 12 academic departments and 3 schools of the University of Pittsburgh. Based upon a retrospective analysis of historical data from January 2010 to April 2014, BOCP members authored or co- authored 517 cancer-related publications, of which 31% resulted from intra-programmatic and 30% from inter- programmatic collaborations. Approximately 54% of the papers represent collaborations with external investigators. Research in the BOCP is supported by an NCI Specialized Program of Research Excellence (SPORE) in Ovarian Cancer shared with Roswell Park Cancer Institute (RPCI), as well as individual federal grants, foundation awards, and philanthropy. BOCP members currently receive a total of $8.2 M in annual direct funding, including $2.6 M from the NCI and $2.1 M in other peer-reviewed grant support. A highly collaborative and interactive group, BOCP members meet regularly at work-in-progress meetings, journal clubs, and a yearly retreat. In addition, the BOCP forges relationships with other programs to enhance the multi-disciplinary nature of breast and ovarian cancer research at UPCI. UPCI support, including Clinical Protocol and Data Management and Shared Resources, specifically the Animal Facility, Biostatistics Facility, Cancer Bioinformatics Services, Cancer Genomics Facility, Cancer Pharmacokinetics and Pharmacodynamics Facility, Cancer Proteomics Facility, Cell and Tissue Imaging Facility, Chemical Biology Facility, Cytometry Facility, Immunological Monitoring and Cellular Products Laboratory, In Vivo Imaging Facility, Investigational Drug Services, and Tissue and Research Pathology Services facilitates and enhances BOCP research.