Peptide-siRNA Nanotherapeutics for Osteoarthritis

肽-siRNA 骨关节炎纳米疗法

• 批准号: 9250285
• 负责人: Christine T. Pham
• 金额: $ 7.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9250285
• 关键词: Affect; Animal Experimentation; Animal Genetics; Animal Model; Applied Research; Arts; Award; Biological Factors; Biology; Biomechanics; Biomedical Engineering; Cells; Collaborations; Communities; Complex; Degenerative polyarthritis; Developmental Biology; Disease; Engineering; Environment; Five-Year Plans; Fostering; Functional disorder; Funding; Gene Expression; Genetic Models; Goals; Grant; Histology; Image; In Situ; Injury; Intervertebral disc structure; Knee; Laboratory Research; Leadership; Malignant Neoplasms; Mechanics; Medicine; Mentors; Metabolic Diseases; Metastatic Neoplasm to the Bone; Methodology; Molecular Analysis; Monitor; Mus; Muscle; Musculoskeletal; Musculoskeletal Diseases; Neoplasm Metastasis; Osteoporosis; Pain; Patients; Peptides; Phenotype; Population; Population Genetics; Publications; Regenerative Medicine; Reporter; Research; Research Personnel; Research Technics; Resources; Schools; Science; Scientist; Series; Services; Shoulder; Small Interfering RNA; Stem cells; Structure; Techniques; Technology; Tendon Injuries; Tendon structure; Testing; Tissues; Training; Training Activity; Training and Education; Translations; United States National Institutes of Health; Universities; Ursidae Family; Washington; Zebrafish; base; bone healing; bone strength; cartilage repair; college; innovation; interdisciplinary approach; interest; lost work time; medical schools; member; morphometry; nanotherapeutic; nervous system disorder; next generation; outreach; programs; ranpirnase; scoliosis; skeletal; stem; symposium

Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B:Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.

在过去的四年里，通过P30 CCMBM赠款提供的机会，我们松散的组织 的肌肉骨骼实验室已经发展成为一个备受尊敬的肌肉骨骼研究中心， 来自22个部门的成员，超过250种出版物（Reporter中有158种），一个拥有12个肌肉骨骼系统的新设施 实验室与行政和研究中心共同定位，这是一个积极和富有成效的试点和可行性研究中心。 计划，一个流行的肌肉骨骼研讨会系列和出席人数众多的年度研讨会。我们的领域 人们对各种常见肌肉骨骼疾病的兴趣已经涵盖了从骨质疏松症到 从骨关节炎到肌腱损伤再到癌症。我们现在有5900万美元的资金，其中3500万美元来自美国国立卫生研究院， 最近获得了Skeleton代谢疾病的T32培训补助金。 在接下来的五年里，我们计划发展我们的中心，以包括更广泛的研究兴趣 源于我们更大和更多样化的研究基础，如癌症转移到骨骼，脊柱侧凸， 椎间盘疾病，肌腱到骨愈合，软骨修复和再生医学中的干细胞。 我们的充实计划将扩大到包括指导活动和培训和教育， 专门的研究技术。CCMBM能够提供许多新服务， 科学的研究基础，如扩大动物模型，包括斑马鱼，隔离 使用组织学和新的非侵入性技术来监测组织质量。 我们的研究核心是：核心B：肌肉骨骼结构和力量，核心C：组织学和 形态测量学和核心D：动物模型。在ICTS的帮助下，我们很高兴能在 强调将我们的动物研究转化为患者。CCMBM将继续提供 领导促进高质量的研究，促进合作和跨学科的方法，扩大 研究基地的行列，并通过提供帮助推动肌肉骨骼研究人员的科学 通过我们的研究核心来开发越来越复杂和强大的技术。