Peptide-siRNA Nanotherapeutics for Osteoarthritis

在过去的四年里，借助P30 CCMBM赠款提供的机会，我们松散的组织 的肌肉骨骼实验室已经发展成为备受尊敬的肌肉骨骼研究中心，拥有75 来自22个部门的成员，超过250份出版物(记者158份)，一个拥有12个肌肉骨骼的新设施 与行政和研究核心共同本地化的实验室，积极和富有成效的试点和可行性 计划，一个广受欢迎的肌肉骨骼研讨会系列和出席人数众多的年度研讨会。我们的田野 人们对各种常见的肌肉骨骼疾病感兴趣，从骨质疏松症到 骨关节炎到肌腱损伤，再到癌症。我们现在有5900万美元的资金，还有来自NIH的3500万美元， 最近还获得了骨骼代谢性疾病T32培训补助金。 在接下来的五年里，我们计划将我们的中心扩大到包括更广泛的研究兴趣 源于我们更大和更多样化的研究基础，如癌症转移到骨、脊柱侧弯和 再生医学中的椎间盘疾病、肌腱到骨的愈合、软骨修复和干细胞。 我们的充实计划将扩大到包括指导活动以及培训和教育 专门的研究技术。CCMBM支持提供许多新服务，这些服务将有助于推动 科学的研究基础，如扩大动物模型，将斑马鱼包括在内，隔离 使用组织学和新的非侵入性技术监测组织质量的特定细胞群。 我们的研究核心是：核心B：肌肉骨骼结构和强度，核心C：组织学和 形态计量学和核心D：动物模型。在ICTS的帮助下，我们非常兴奋地包括了一个新的 强调将我们的动物研究转化为患者。CCMBM将继续提供 在促进高质量研究方面发挥领导作用，促进合作和跨学科方法，扩大 研究基地的队伍，并通过提供 通过我们的研究核心，我们拥有越来越复杂和强大的技术。

Over the past four years with the opportunity provided by the P30 CCMBM grant, our loosely organized set of musculoskeletal labs has developed into a well respected Musculoskeletal Research Center with 75 members from 22 Departments, over 250 publications (158 in Reporter), a new facility with 12 musculoskeletal labs co-localized with the Administration and Research Cores, an active and productive Pilot and Feasibility Program, a popular Musculoskeletal Seminar Series and well-attended Annual Symposia. Our fields of interest have covered a wide variety of common musculoskeletal disorders from osteoporosis to osteoarthritis to tendon injuries to cancer. We now have $59 million in funding with $35 million from the NIH, and were recently awarded a T32 Training grant in Skeletal Metabolic Diseases. During the next five years, we plan to grow our Center to include a wider range of research interests stemming from our larger and more diverse research base, such as cancer metastasis to bone, scoliosis and intervertebral disc disease, tendon to bone healing, cartilage repair and stem cells in regenerative medicine. Our enrichment program will be expanded to include mentoring activities and training and education in specialized research techniques. The CCMBM enables the offering of many new services that will help drive the science of the research base, such as an expansion of the animal models to include zebrafish, isolation of specific populations of cells using histology and new non-invasive techniques to monitor tissue quality. Our Research Cores are: Core B:Musculoskeletal Structure and Strength, Core C: Histology and Morphometry, and Core D: Animal Models. With the help of the ICTS, we are very excited to include a new emphasis on translation of our animal research to the patient. The CCMBM will continue to provide leadership in promoting quality research, foster collaborations and interdisciplinary approaches, expand the ranks of the research base and help drive the science of musculoskeletal investigators by providing increasingly sophisticated and powerful technologies through our research cores.