Multiplexed Point Of Care Nucleic Acid Assay for STI

 描述（由申请人提供）：每年有近2000万新感染者，性传播疾病（STD）在美国非常常见。随着最近国家医疗保健格局的变化，包括《平价医疗法案》的通过和国家预算削减导致性病和艾滋病毒诊所关闭，初级保健提供者预计将遇到更多的性病患者。对妇女和婴儿来说，性传播疾病可能产生严重和长期的后果，包括不孕症、促进艾滋病毒感染、生殖道癌、盆腔炎和围产期不良后果。性病每年花费美国医疗保健系统近160亿美元。在初级保健诊所和市中心诊所获得容易获得和敏感的基于核酸的护理点（POC）测试的能力可能对该国的性病发病率产生深远的影响。从建模和成本效益分析来看，快速、准确、灵敏的诊断测试的底线是明确的--当我们拥有它们时，我们应该使用它们。我们建议开发快速，准确，灵敏和具有成本效益的基于核酸的POC系统，以满足未满足的市场需求。该系统可以很容易地扩展到包括其他测试在未来，包括艾滋病毒载量，肝炎，梅毒，MGen，HPV和BV。

 DESCRIPTION (provided by applicant): With nearly 20 million new infections annually, sexually transmitted diseases (STDs) are very common in the United States. And with recent changes to the national health care landscape, including the passage of the Affordable Care Act and state budget cuts resulting in the closure of STD and HIV clinics, primary care providers can expect to encounter more patients with STDs. For women and infants, STDs can have serious and long-term consequences, including infertility, facilitation of HIV infection, reproductive trac cancer, pelvic inflammatory disease, and poor perinatal outcomes. STDs cost the US health care system nearly $16 billion every year. The ability to obtain easily available and sensitive Nucleic Acid Based Point Of Care (POC) tests in primary care clinics and inner city clinics may have a far reaching impact on the rates of STDs in this country. From modeling and cost-benefit analyses the bottom line for rapid, accurate, sensitive diagnostic tests is clear - when we have them, we should use them. We propose to develop rapid, accurate, sensitive and cost effective Nucleic Acid based POC system to fulfill the unmet market needs. The system can be readily expanded to include other tests in the future including HIV-Viral load, Hepatitis, Syphilis, MGen, HPV and BV.