Core Support for Hearing Research - "NIDCD" Research Core Center P30

产品说明：三个研究核心建议，以促进跨学科研究听力和耳聋在马萨诸塞州眼耳医院。该研究中心由23名高级研究员和9名初级研究员组成，均隶属于伊顿-皮博迪实验室（EPL）。他们包括临床医生和基础科学家，与哈佛医学院和麻省理工学院的研究生课程和部门有学术联系。研究基地涵盖了广泛的基础和应用研究项目，从外周力学到皮层处理，从体外系统到人类患者，从动物模型到神经网络。三个核心和每个核心的主要目标包括：1）工程核心，设计，建造，编程和维护数据采集系统，定制声学设备和刺激生成系统，提供精密加工服务，为各种研究应用构建定制机械设备，并与更大的科学界分享这些软件和硬件进步; 2）组织学-外科核心，以维持现有的共享设施，协助研究团队进行动物手术和光学和电子显微镜的组织学准备，并不断提高整个中心的组织学和外科准备的质量;和3）成像核心，以支持数字图像采集和分析，包括共聚焦显微镜、透射电子显微镜、计算机辅助解剖重建、形态测定自动化、3-D重建/绘制，分析功能成像数据，并与更大的科学界分享虚拟教学模型。

DESCRIPTION: Three Research Cores are proposed to facilitate interdisciplinary research into hearing and deafness at the Massachusetts Eye and Ear Infirmary. The Research Center comprises 23 senior investigators and 9 junior investigators, all affiliated with the Eaton-Peabody Laboratory (EPL). They include clinicians and basic scientists, with academic ties to graduate programs and departments at Harvard Medical School and MIT. The Research Base covers a wide range of basic and applied research projects from peripheral mechanics to cortical processing, from in vitro systems to human patients, from animal models to neural nets. The three Cores and the major aims of each include 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, to provide a precision machining service to build custom mechanical devices for a wide variety of research applications, and to share these software and hardware advances with the greater scientific community; 2) a Histology-Surgery Core to maintain existing shared facilities, to assist research teams in animal surgery and histological preparation for both light and electron microscopy and to continually enhance the quality of both histological and surgical preparations throughout the center; and 3) an Imaging Core to support digital image-acquisition and analysis, including confocal microscopy, transmission electron microscopy, computer-aided anatomical reconstruction, automation of morphometry, 3-D reconstruction/rendering, analysis of functional imaging data, and to share virtual teaching models with the greater scientific community.