Data management and analysis core

数据管理与分析核心

• 批准号: 9096223
• 负责人: Gordon James Ramsay
• 金额: $ 7.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9096223
• 关键词: Address; Autistic Disorder; Behavioral; Biometry; Clinical; Collection; Custom; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Early Diagnosis; Ensure; Environment; Genes; Goals; Growth; Human Resources; Individual; Life; Maps; Measures; Modeling; Phylogeny; Procedures; Process; Publications; Quality Control; Research; Research Infrastructure; Resource Sharing; Retrieval; Risk; Sampling; Scientist; Software Engineering; Software Tools; Statistical Data Interpretation; Supercomputing; Techniques; Training; Translating; base; computer infrastructure; computerized data processing; data management; data sharing; database design; innovation; mathematical analysis; meetings; novel; programs; repository; resilience; social; success; transmission process

The objective of the Emory ACE Data Management & Analysis Core is to create an optimal scientific and technical environment for creating growth charts of social engagement from densely-sampled longitudinal data sets co-registered across multiple domains in order to explore mechanisms of risk and resilience in autism, a key aim of Projects l-V as well as the whole program project. To accomplish this goal, the Core will provide shared resources, facilities and expertise for data collection, processing, analysis, storage and retrieval to serve the entire program project, as well as acting as a common repository for sharing data between individual projects and transmitting results to NDAR. The specific aims of the Core are: (1) Data Management: to meet the uniquely challenging data processing, management, storage and transmission needs of the entire program project; (2) Data Analysis: to provide a common methodological framework and shared computational infrastructure for carrying out state-of-the-art developmental profiling and statistical analysis of experimental measures collected across Projects l-V; (3) Training and Reliability: to provide common training in all of the novel data analysis techniques employed across projects, and to ensure that those techniques are deployed consistently and reliably across projects, using appropriate procedures for data management; and (4) Quality Control: to ensure that all data arising from the program project are of uniformly and exceptionally high quality, suitable for publication, submission to NDAR, and immediate use by other scientists. Key personnel will provide expertise in mathematical analysis, biostatistics, software engineering, and data processing needed to achieve the specific aims of each project. Shared facilities and infrastructure will be made available to support the data management and analysis needs of each project, including a central supercomputing facility, local workstations, and a suite of software tools customized for the data processing required in each project. Data management will be centralized on a common data server using RexDB, a custom-designed database commissioned from Prometheus Research specifically to handle large-volume clinical, behavioral, and experimental data sets, and their transmission to NDAR.

埃默里ACE数据管理与分析核心的目标是创建一个最佳的科学和技术环境，用于从密集采样的纵向数据集中创建社会参与的增长图表，这些数据集跨多个领域共同注册，以探索自闭症风险和恢复力的机制，这是项目l-V以及整个项目的关键目标。为了实现这一目标，Core将为整个项目提供数据收集、处理、分析、存储和检索的共享资源、设施和专业知识，并充当单个项目之间共享数据的公共存储库，并将结果传输给NDAR。核心的具体目标是：(1)数据管理：满足整个计划项目独特的具有挑战性的数据处理、管理、存储和传输需求；(2)数据分析：提供一个共同的方法框架和共享的计算基础设施，用于对项目l-V收集的实验措施进行最先进的发展概况和统计分析；(3)培训和可靠性：提供跨项目使用的所有新颖数据分析技术的通用培训，并使用适当的数据管理程序确保这些技术在跨项目中得到一致和可靠的部署；(4)质量控制：确保计划项目中产生的所有数据具有统一和极高的质量，适合发表，提交给NDAR，并可供其他科学家立即使用。关键人员将提供数学分析、生物统计学、软件工程和数据处理方面的专业知识，以实现每个项目的具体目标。将提供共享设施和基础设施，以支持每个项目的数据管理和分析需求，包括中央超级计算设施、本地工作站和为每个项目所需的数据处理定制的一套软件工具。数据管理将集中在使用RexDB的公共数据服务器上，RexDB是Prometheus Research委托定制设计的数据库，专门用于处理大量临床、行为和实验数据集，并将其传输到NDAR。