Development of smoking cessation interventions informed by temporal discounting

描述(由申请人提供)：本独立科学家奖(K02)申请书寻求资金，使PI能够将其关于时间贴现过程的基础研究转化为理论和经验上知情的干预措施，用于治疗 成瘾和相关的障碍。职业发展计划将允许PI获得干预开发和测试方面的培训，这将促进基础/实验和临床研究之间的协同关系。这一培训将有助于PI努力打开这些互补研究领域之间的沟通渠道；不仅基础/实验研究将为创新干预提供信息，而且基础/实验研究问题也将通过临床见解、结果和限制获得信息。这一培训将涉及以下相互关联的领域：临床干预的基本原理、干预措施的开发和修改过程、干预测试和临床试验的进行，以及临床试验研究的数据管理和分析。培训还将涉及有助于将基础研究转化为干预措施的研究领域(神经科学和认知科学)。这些职业发展目标将通过咨询、研究活动以及与干预开发和测试、生物统计学、神经科学和认知科学领域的知名研究人员的合作来实现。课堂和技术培训以及参加科学会议、讲习班和研究所将有助于拟议的职业发展。拟议的教学和职业发展活动与基于非常有希望的数据的研究计划紧密结合在一起，这表明解释水平理论可以提供减少时间折扣的方法。这项研究试图将这一重要的发现--药物戒断的预测因素--转化为戒烟干预。独立科学家奖将为PI提供必要的保护时间，以发展干预开发和测试研究中的新技能。这些新技能将促进PI对时间折扣基本过程的研究在临床上的应用，以开发针对吸烟、其他药物滥用和相关行为障碍的创新干预措施。

DESCRIPTION (provided by applicant): This application for an Independent Scientist Award (K02) seeks funding that would enable the PI to translate his basic research on temporal discounting process into theoretically- and empirically-informed interventions for the treatment of addiction and related disorders. The career development plan will allow the PI to obtain training in intervention development and testing that will facilitate a synergistic relationship between basic/experimental and clinical research. This training will contribute to the PI's effort to open the lines of communication between these complementary areas of research; not only will innovative interventions to be informed by basic/experimental research, but basic/experimental research questions can then be informed by clinical insights, outcomes, and limitations. This training will involve the following interrelated areas: fundamentals of clinical interventions, processes of intervention development and modification, intervention testing and conduct of clinical trials, and data management and analysis of clinical trials research. Training will also involve research areas (neuroscience and cognitive science) that will contribute to translation of basic research into interventions. These career development goals will be met through consultation, research activities, and collaborations with established researchers in the areas of intervention development and testing, biostatistics, neuroscience, and cognitive science. Classroom and technical training as well as attendance at scientific meetings, workshops, and institutes will contribute to the proposed career development. The proposed didactic and career development activities are closely coupled with the research plan that is based on highly promising data indicating that Construal Level Theory can inform approaches to reduce temporal discounting. This research seeks to translate this significant finding, a predictor of dru abstinence, into a smoking cessation intervention. An Independent Scientist Award will provide the needed protected time for the PI to develop new skills in the study of intervention development and testing. These new skills will facilitate the clinical application of the PI's research on basic processes of temporal discounting, towards the development of innovative interventions addressing cigarette smoking, other drugs of abuse, and related behavioral disorders.