The Kentucky Pediatric Clinical Trials Rural/Urban Partnership

肯塔基州儿科临床试验农村/城市合作伙伴关系

• 批准号: 9461971
• 负责人: JANICE E SULLIVAN
• 金额: $ 148.76万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-23 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9461971
• 关键词: Kentucky; Pediatric; Clinical; Trials; Rural

PROJECT SUMMARY/ABSTRACT As a predominantly rural state, Kentucky leads the nation in many pediatric and adult chronic and environmentally-related diseases and ‘ranks nationally’ in low educational achievement. These adverse factors combine to make Kentuckians especially unhealthy residents with a high prevalence of obesity, diabetes, smoking, alcohol use, heart disease, stroke, lung cancer, etc. Many of these diseases are environmentally related to poor nutrition, obesity, smoking, drug abuse and work-place exposures. Kentucky also leads the nation in the percentage of pediatric populations with special health care needs. Prior work has shown that most adult diseases begin in childhood and some begin during intrauterine exposure, making childhood the ideal time for intervention with the goal of improving health outcomes into adulthood. Improving healthcare outcomes and wellness in children is contingent on expanding high quality clinical research to include more diverse populations. Pediatricians at the University of Louisville (UofL) with our Healthcare Partners serve a highly diverse patient population that includes the rural and urban poor, a unique Appalachian community, refugees and numerous ethnic minorities. In order to better serve this population, we propose to build upon our current programs, expand our bidirectional community engagement efforts, collaborate with other institutions on pediatric clinical trials through the IDeA Pediatric Trials Network, and collaborate with ECHO and CHEAR sites to advance healthcare for children. The Kentucky-Pediatric IDeA Research Center (K-PIRC), as part of the IDeA States Pediatric Clinical Trial Network, will make it possible for 1) underserved rural and urban infants, children and adolescents to participate in clinical research; 2) junior investigators to be trained in clinical research and community engagement, improve the health of both children and adults in Kentucky through this research, and develop their academic career; and 3) create a regional network of partners to sustain this clinical research initiative. The four primary focus areas of research are 1) upper and lower airway disease; 2) obesity; 3) pre-, peri- and postnatal outcomes; and 4) neurodevelopmental outcomes. These primary focus areas have a high prevalence in Kentucky therefore K-PIRC will enable strengthening current collaborations and accelerate the development of new networks within the state through bidirectional community engagement and feedback to support pediatric clinical research. Ultimately through these efforts the health outcomes of Kentucky children and adults will improve and a sustainable pediatric clinical research workforce locally and nationally will be established.

项目总结/摘要 作为一个以农村为主的州，肯塔基州在许多儿童和成人慢性和 与环境有关的疾病和“全国排名”的低教育成就。这些不利因素 联合收割机使肯塔基州居民特别不健康，肥胖，糖尿病， 吸烟、酗酒、心脏病、中风、肺癌等。这些疾病中有许多是环境因素造成的。 与营养不良、肥胖、吸烟、滥用药物和工作场所接触有关。肯塔基州也领先于 有特殊保健需要的儿童人口的百分比。先前的工作表明， 大多数成人疾病开始于儿童时期，有些开始于宫内暴露期间， 这是进行干预的理想时机，目的是改善成年后的健康状况。 改善儿童的医疗保健结果和健康取决于扩大高质量的临床 研究包括更多样化的人群。路易斯维尔大学（UofL）的儿科医生与我们的 医疗保健合作伙伴为高度多样化的患者群体提供服务，其中包括农村和城市贫困人口，这是一个独特的 阿巴拉契亚社区，难民和许多少数民族。为了更好地服务这一群体，我们 建议在我们现有计划的基础上，扩大我们的双向社区参与努力， 通过IDEA儿科试验网络与其他机构合作进行儿科临床试验， 与ECHO和CHEMICAL站点合作，推进儿童医疗保健。 肯塔基州儿童IDEA研究中心（K-PIRC），作为IDEA州儿童临床试验的一部分 网络，将使1）服务不足的农村和城市婴儿，儿童和青少年， 参与临床研究; 2）初级研究者接受临床研究和社区培训 参与，通过这项研究改善肯塔基州儿童和成人的健康，并发展 他们的学术生涯;和3）创建一个合作伙伴的区域网络，以维持这一临床研究倡议。 研究的四个主要重点领域是：1）上呼吸道和下呼吸道疾病; 2）肥胖; 3）术前、术后和术后 产后结果;和4）神经发育结果。这些主要重点领域具有很高的 在肯塔基州的患病率，因此K-PIRC将能够加强目前的合作，并加速 通过双向社区参与和反馈， 支持儿科临床研究。最终通过这些努力，肯塔基州儿童的健康状况 成人将得到改善，地方和国家的可持续儿科临床研究队伍将 确立了习