IGF::OT::IGF R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

IGF::OT::IGF R

• 批准号: 9152553
• 负责人: ZONGXING WANG
• 金额: $ 30万
• 依托单位: OMEGA OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-22 至 2016-06-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9152553
• 关键词: Basic Science; Cells; Coupled; DNA; Data; Detection; Devices; Diagnostic; Disease; Hospitals; Label; Malignant Neoplasms; Medical; Methodist Church; MicroRNAs; Microfluidics; Modeling; Monitor; Nucleic Acids; Optics; Patients; Pattern; Phase; Reporting; Research Institute; Sampling; Sensitivity and Specificity; Serum; Silicon; System; Texas; Universities; Water; Writing; austin; base; cancer diagnosis; design; novel; photonics; programs; research and development; research study; simulation

In this proposal, Omega Optics Inc., the University of Texas at Austin and Houston Methodist Hospital Research Institute jointly propose an integrated lab-on-chip system that can isolate exosomes and microvesicles from serum using ciliated micropillar array and perform multiplexing miRNA detection using label-free microarray based on multiple photonic crystal microcavity device coupled to a photonic crystal waveguide. The proposed program will develop a portable diagnostic device suitable for hightly parallel, label-free cancer diagnosis based on miRNA identification. The system can detect cancer with high sensitivity and specificity using patient serum sample. The novel system design and integration can be easily extended to many other diseases detection by analyzing cell free nucleic acid.

在这项提案中，欧米茄光学公司，德克萨斯大学奥斯汀分校和休斯顿卫理公会医院研究所联合提出了一种集成的芯片实验室系统，该系统可以使用纤毛微柱阵列从血清中分离外泌体和微泡，并使用基于耦合到光子晶体波导的多光子晶体微腔装置的无标记微阵列进行多路复用miRNA检测。 该计划将开发一种便携式诊断设备，适用于基于miRNA识别的高度并行、无标记的癌症诊断。 该系统可以使用患者血清样本以高灵敏度和特异性检测癌症。 这种新的系统设计和集成可以很容易地扩展到许多其他疾病的检测，通过分析无细胞核酸。