IGF::OT::IGF R&D- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

在该提案中，Omega Optics Inc.，德克萨斯大学奥斯汀分校和休斯顿卫理公会医院研究所联合提出了一种集成的实验室芯片系统，该系统可以使用纤毛微柱阵列从血清中分离外泌体和微泡，并使用基于多光子晶体微腔器件耦合到光子晶体波导的无标记微阵列进行多路miRNA检测。该计划将开发一种便携式诊断设备，适用于基于miRNA鉴定的高度并行、无标签的癌症诊断。该系统利用患者血清样本检测癌症，具有较高的灵敏度和特异性。这种新颖的系统设计和集成可以很容易地扩展到通过分析游离核酸来检测许多其他疾病。

In this proposal, Omega Optics Inc., the University of Texas at Austin and Houston Methodist Hospital Research Institute jointly propose an integrated lab-on-chip system that can isolate exosomes and microvesicles from serum using ciliated micropillar array and perform multiplexing miRNA detection using label-free microarray based on multiple photonic crystal microcavity device coupled to a photonic crystal waveguide. The proposed program will develop a portable diagnostic device suitable for hightly parallel, label-free cancer diagnosis based on miRNA identification. The system can detect cancer with high sensitivity and specificity using patient serum sample. The novel system design and integration can be easily extended to many other diseases detection by analyzing cell free nucleic acid.