Manipulating Tobacco Constituents in Female Menthol Smokers

控制女性薄荷醇吸烟者的烟草成分

• 批准号: 9127914
• 负责人: Cheryl A Oncken
• 金额: $ 65.44万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127914
• 关键词: 1-Butanol; Abstinence; Advisory Committees; Age; Area; Carbon Monoxide; Cigarette; Cotinine; Esthesia; Exhalation; Extinction (Psychology); Female; Flavoring; Genetic Variation; Genotype; Haplotypes; Health; Masks; Measures; Mediating; Menthol; Nicotine; Nicotine Dependence; Nitrosamines; Perception; Process; Property; Propylthiouracil; Randomized; Receptor Gene; Reporting; Research; Rewards; Self Efficacy; Smell Perception; Smoke; Smoker; Smoking; Smoking Behavior; Stimulus; Taste Buds; Taste Perception; Testing; Time; Tobacco; Tobacco Dependence; Toxicant exposure; Vulnerable Populations; Withdrawal; Woman; authority; aversive conditioning; craving; design; follow-up; men; negative affect; operation; population based; reproductive; response; satisfaction; smoking cessation; urinary

DESCRIPTION: The FDA has the regulatory authority to reduce, but not eliminate, nicotine from cigarettes. It also has the authority to ban menthol from cigarettes, as has been recommended by the Tobacco Products Scientific Advisory Committee. The purpose of this study is to examine the potential impact of these two regulatory actions alone and in combination in female menthol smokers. This line of inquiry responds to FDA suggested areas for research including 1) What are the potential effects of menthol on appeal of tobacco products and the impact of cessation?; 2) How do reductions in nicotine influence consumer perceptions and ability to quit tobacco?; 3) How does genetic variation in sensitivity to flavorings and taste influence tobacco addiction?; 4) What is the impact of menthol and reduced nicotine content cigarettes (RNC) in a vulnerable population such as women of reproductive age? We propose a 2x 2 design in which 320 non-treatment seeking female menthol smokers will be randomized to switch to reduced nicotine content cigarettes (RNC), reduced nicotine content menthol cigarettes (RNC-Men), conventional nicotine non-menthol cigarettes (CN), or to conventional nicotine-menthol cigarettes of their own brand (CN-Men), for six weeks with an additional six week follow-up. We will examine the effects of reducing nicotine content and/or removing menthol from cigarettes on measures of smoking behavior, nicotine dependence and cigarette abstinence in female menthol smokers. We hypothesize that female menthol smokers randomized to any of the modified content cigarettes (CN, RNC, RNC-Men) will smoke fewer cigarettes per day compared to those in the CN-Men conditions. We will also examine the effects of these cigarette content manipulations on measures of toxicant exposure, examine mechanisms by which content manipulations may decrease smoking behavior (by examining measures that reflect operation of extinction and aversive conditioning processes), and explore the moderating effect of genetic variation in taste receptor genes on response to switching to experimental cigarettes.

描述：FDA 有权减少但不能消除香烟中的尼古丁。根据烟草产品科学咨询委员会的建议，它还有权禁止在卷烟中添加薄荷醇。本研究的目的是检查这两种监管措施单独和联合对女性薄荷醇吸烟者的潜在影响。这一调查系列回应了 FDA 建议的研究领域，包括 1) 薄荷醇对烟草产品吸引力的潜在影响以及戒烟的影响是什么？ 2) 尼古丁含量的减少如何影响消费者的认知和戒烟能力？； 3）对调味品和味道的敏感性的遗传变异如何影响烟草成瘾？ 4) 薄荷醇和低尼古丁含量香烟 (RNC) 对育龄妇女等弱势群体有何影响？我们提出了一种 2x 2 设计，其中 320 名未寻求治疗的女性薄荷醇吸烟者将被随机转换为低尼古丁含量香烟（RNC）、低尼古丁含量薄荷醇香烟（RNC-Men）、传统尼古丁非薄荷醇香烟（CN）或他们自己品牌的传统尼古丁薄荷醇香烟（CN-Men），为期六周，另外六周 后续行动。我们将研究降低尼古丁含量和/或去除香烟中的薄荷醇对女性薄荷醇吸烟者的吸烟行为、尼古丁依赖和戒烟的影响。我们假设，与 CN-Men 条件下的女性相比，随机吸食任何改良成分香烟（CN、RNC、RNC-Men）的女性薄荷醇吸烟者每天吸的香烟数量会更少。我们还将研究这些香烟内容操纵对有毒物质暴露测量的影响，检查内容操纵可能减少吸烟行为的机制（通过检查反映消退和厌恶条件作用过程的操作的措施），并探索味觉受体基因的遗传变异对改用实验香烟的反应的调节作用。