OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment Mechanisms

OCD:识别疾病和治疗机制的新比较基因组方法

基本信息

项目摘要

PROJECT SUMMARY In this study we seek to understand how genetic and environmental factors jointly influence both the risk of developing Obsessive-Compulsive Disorder (OCD) and the outcome of treatment interventions. OCD and related disorders are of major public health importance owing to their profound personal and societal costs. Little is known for certain about their etiology, and treatment, detection and prevention strategies are not optimal or directed by knowledge of pathophysiology. In other psychiatric disorders (e.g., schizophrenia, bipolar disorder and autism), genomics has begun to deliver fundamental knowledge about genetic architecture, identify specific loci for biological follow-up and localize pathways altered in disease. We intend to realize these same advances for OCD by markedly increasing the worldwide sample size for genomic analysis, in a first step toward elucidating the fundamental biology of this condition. Three overlapping areas will be investigated in this project. First, we will collect the world's largest richly phenotyped sample of OCD cases (N = 10,000). To do this in an efficient and cost-effective manner, we will take advantage of an ongoing nationwide OCD treatment study in Norway and a network of active OCD clinics in Sweden. The phenotypes will include a detailed clinical characterization (e.g., comorbidities, symptom dimensions, treatment response) and links to the Swedish and Norwegian registers, facilitating gene by environment interaction studies. Second, we will genotype all 10,000 samples on the PsychChip GWAS array (genotypes for >30,000 matched controls are already available). This will allow us to discover genomic loci harboring common and rare variation associated with OCD. We will also incorporate a novel comparative genomic approach to interpret these genomic data, capitalizing on an animal model with high face and construct validity: canine compulsive disorder. Third, we will calculate individual risk profile scores (GRS) as a measure of genetic liability to OCD and test for interactions between genetic liability and a range of clinical (e.g., response to treatment), epidemiological (e.g., paternal age, obstetric complications, early life adversity, socioeconomic status) and genetic epidemiological (e.g., family history) variables from the Swedish and Norwegian registers. We expect this study to improve our understanding of the causal mechanisms implicated in OCD, with a view towards improving clinical outcomes and reducing chronicity and societal costs.
项目总结

项目成果

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James Joseph Crowley其他文献

James Joseph Crowley的其他文献

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{{ truncateString('James Joseph Crowley', 18)}}的其他基金

1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder
强迫症的1/2跨祖先基因组分析
  • 批准号:
    10261855
  • 财政年份:
    2021
  • 资助金额:
    $ 65.09万
  • 项目类别:
1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder
强迫症的1/2跨祖先基因组分析
  • 批准号:
    10646445
  • 财政年份:
    2021
  • 资助金额:
    $ 65.09万
  • 项目类别:
Administrative Supplement: 1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder
行政补充:强迫症的1/2跨血统基因组分析
  • 批准号:
    10818832
  • 财政年份:
    2021
  • 资助金额:
    $ 65.09万
  • 项目类别:
1/2 Trans-ancestry genomic analysis of obsessive-compulsive disorder
强迫症的1/2跨祖先基因组分析
  • 批准号:
    10478300
  • 财政年份:
    2021
  • 资助金额:
    $ 65.09万
  • 项目类别:
2/2 Rare Genetic Variation and Risk for Obsessive Compulsive Disorder
2/2 罕见的基因变异和强迫症的风险
  • 批准号:
    10516725
  • 财政年份:
    2020
  • 资助金额:
    $ 65.09万
  • 项目类别:
2/2 Rare Genetic Variation and Risk for Obsessive Compulsive Disorder
2/2 罕见的基因变异和强迫症的风险
  • 批准号:
    10318565
  • 财政年份:
    2020
  • 资助金额:
    $ 65.09万
  • 项目类别:
2/2 Rare Genetic Variation and Risk for Obsessive Compulsive Disorder
2/2 罕见的基因变异和强迫症的风险
  • 批准号:
    10095318
  • 财政年份:
    2020
  • 资助金额:
    $ 65.09万
  • 项目类别:
Investigating the molecular mechanisms and consequences of assortative mating in major psychiatric disorders: completing a missing piece of the psychiatric genetics puzzle
研究主要精神疾病中选型交配的分子机制和后果:完成精神遗传学难题中缺失的一块
  • 批准号:
    9545065
  • 财政年份:
    2017
  • 资助金额:
    $ 65.09万
  • 项目类别:
OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment Mechanisms
OCD:识别疾病和治疗机制的新比较基因组方法
  • 批准号:
    10161830
  • 财政年份:
    2016
  • 资助金额:
    $ 65.09万
  • 项目类别:
OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment Mechanisms
OCD:识别疾病和治疗机制的新比较基因组方法
  • 批准号:
    9691493
  • 财政年份:
    2016
  • 资助金额:
    $ 65.09万
  • 项目类别:

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