Functional Integrity of the Aging Auditory Synapse
Functional Integrity of the Aging Auditory Synapse
批准号:
9151173
负责人:
Anthony J Ricci
金额:
$27.59万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-01 至 2021-05-31
关键词:
AddressAgeAgingAnimal ModelAnimalsAuditoryAuditory Brainstem ResponsesCalciumCalcium ChannelCell physiologyCochleaCochlear nucleusCollaborationsComplexDataDeteriorationEarly InterventionElectric CapacitanceElectrophysiology (science)ElementsEnsureEnvironmentFiberFrequenciesFunctional disorderGeneticGlutamatesGoalsHair CellsHearingHomeostasisImageImmuneInbred CBA MiceIon ChannelLeadMaintenanceMeasurementMeasuresMechanicsModelingMolecularMonitorMusMutationNeuraxisNoise-Induced Hearing LossOpticsOrganPathway interactionsPhysiologicalPresbycusisProcessPropertyProteinsQuality of lifeResearchResearch PersonnelSignal TransductionSiteSupporting CellSynapsesSynaptic PotentialsSynaptic TransmissionSynaptic VesiclesSystemTechniquesTechnologyTestingTimeVesicleWidthWorkabstractingassociated symptomelectrical propertyelectron tomographyganglion cellhearing impairmentloss of functionmouse modelnerve supplynovelotoacoustic emissionpostsynapticpresynapticsensorsocioeconomicssoundspiral ganglionsynaptic functiontime usetraffickingvesicular releasevibration
中文摘要
摘要:年龄相关性听力损失(ARHL)对生活质量有着重大影响,
超过70%的70岁以上的人。这是一个日益严重的问题,
社会经济影响。ARHL的原因很复杂,可能涉及两个方面
环境和遗传因素。与ARHL相关的症状,特别是
在嘈杂环境中辨别声音的能力最初丧失,
随着时间的推移,频率损失可以进一步发展到较低的频率,建议
与初始触发无关的常见漏洞。我们假设,
ARHL的共同点是毛细胞传入纤维突触的初始损失。就像
噪音引起的听力损失,我们假设高阈值纤维的选择性损失。我们
将使用ARHL的多个遗传小鼠模型来测试这些假设。每个售价
使用包括听觉脑干反应的整个动物听觉测试进行监测
和畸变产物耳声发射来记录
每个型号的ARHL。具体目标2将评估突触维持和蛋白质
与突触前和突触后元件相关联,以进一步表征时间
与听力损失相关的窗口。Specific Aim 3将使用电生理学和
光学技术测量突触囊泡的释放和运输,监测钙离子浓度,
稳态和记录突触后特性突触电位以及电
特性.每一个目标都很好地与目标和技术相结合,
每个其他研究人员对这一建议,我们将共同确定一个全球性的
在这个框架中,解决这一重要的翻译问题。
英文摘要
Abstract: Age related hearing loss (ARHL) has a major impact on quality of life of more
than 70% of those over the age of 70. It is a growing problem with significant
socioeconomic ramifications. The cause of ARHL is complex and likely involves both
environmental and genetic factors. Symptoms associated with ARHL, specifically, the
initial loss of ability to discriminate sound in a noisy environment that progress to high
frequency loss that can further progress to lower frequencies over time, suggest a
common vulnerability that is independent of the initial trigger. We are postulating that
common to ARHL is an initial loss of hair cell afferent fiber synapses. Much as with
noise induced hearing loss, we hypothesize a selective loss of high threshold fibers. We
will test these hypotheses using multiple genetic mouse models of ARHL. Each will be
monitored using whole animal auditory testing including auditory brainstem responses
and distortion product otoacoustic emissions to document the time course of onset of
ARHL in each model. Specific Aim 2 will evaluate synaptic maintenance and proteins
associated with pre and postsynaptic elements to further characterize the temporal
windows associated with hearing loss. Specific Aim 3 will use electrophysiological and
optical technologies to measure synaptic vesicle release and trafficking, monitor calcium
homeostasis and record postsynaptic properties synaptic potentials as well as electrical
properties. Each aim is well integrated with the goals and techniques available from
each of the other investigators on this proposal and together we shall identify a global
framework in which to address this important translational problem.
期刊论文(0)
专著(0)
科研奖励(0)
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Identifying new sensors for in vivo cochlear imaging
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Developing Non-Ototoxic Aminoglycosides
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批准号:8336858
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2-photon imaging system
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批准号:7792526
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Calcium Regulation of Mechanotransduction
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批准号:7850399
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财政年份:2009
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负责人:Anthony J Ricci
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依托单位:
Synaptic specialization of auditory hair cells
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批准号:7992365
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项目类别:
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资助金额:$32.89万
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财政年份:2008
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负责人:Anthony J Ricci
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依托单位:
Synaptic specialization of auditory hair cells
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批准号:7744025
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项目类别:
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资助金额:$33.98万
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财政年份:2008
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负责人:Anthony J Ricci
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依托单位:
Synaptic specialization of auditory hair cells
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批准号:7600679
-
项目类别:
-
资助金额:$35.59万
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财政年份:2008
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负责人:Anthony J Ricci
-
依托单位:
Synaptic specialization of auditory hair cells
-
批准号:8374114
-
项目类别:
-
资助金额:$31.26万
-
财政年份:2008
-
负责人:Anthony J Ricci
-
依托单位:
Synaptic Specializations in Auditory Hair Cells
-
批准号:9043021
-
项目类别:
-
资助金额:$47.21万
-
财政年份:2008
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负责人:Anthony J Ricci
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依托单位:
Synaptic Specializations in Auditory Hair Cells
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批准号:9456714
-
项目类别:
-
资助金额:$47.12万
-
财政年份:2008
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负责人:Anthony J Ricci
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依托单位:
Synaptic specialization of auditory hair cells
-
批准号:8196868
-
项目类别:
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资助金额:$32.9万
-
财政年份:2008
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负责人:Anthony J Ricci
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依托单位:
Three-dimensional and Multiscale Organ of Corti Biomechanics
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批准号:8327994
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项目类别:
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资助金额:$49.44万
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财政年份:2007
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负责人:Anthony J Ricci
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依托单位:
Three-dimensional and Multiscale Organ of Corti Biomechanics
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批准号:8685757
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资助金额:$56.15万
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财政年份:2007
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依托单位:
Three-dimensional and Multiscale Organ of Corti Biomechanics
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批准号:8490334
-
项目类别:
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资助金额:$53.61万
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财政年份:2007
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负责人:Anthony J Ricci
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依托单位:
New technologies for investigating the hair cell afferent fiber synapse
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批准号:7279885
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项目类别:
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资助金额:$19.45万
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财政年份:2006
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负责人:Anthony J Ricci
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依托单位:
New technologies for investigating the hair cell afferent fiber synapse
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批准号:7077900
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项目类别:
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资助金额:$25.33万
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财政年份:2006
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负责人:Anthony J Ricci
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依托单位:
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