Effect of Waterpipe Tobacco Ingredients on Human Puffing, Exposures and Appeal

项目摘要 水烟斗(WP)吸烟已经超过了吸烟，现在可以与电子烟相媲美 在美国年轻人中最受欢迎的烟草产品类别。这可能是由于甜食的可用性， 水果和糖果味的烟草使吸入烟草烟雾更具吸引力。目前还不清楚是什么 在不断增加的吸引力方面，最重要的是：吸烟者对甜味或味道的感知，或者两者兼而有之。可湿性粉剂 烟草是独一无二的，因为它的添加剂的数量和特性以及它的吸烟方式。这个 调味品和高水平的甜味保湿剂会产生有害和潜在有害的成分 吸烟，并被认为对使用者造成直接和间接的伤害。要定义 特定化学成分对吸烟者甜味和受欢迎程度的影响，WP烟草 不同之处只在于必须使用感兴趣的变量。没有一套商业上可用的烟草 品牌，因此我们建议操纵商业产品，以适当地隔离 重要的变数。围绕可湿性粉剂烟草添加剂的影响存在一个现有的数据缺口，即， 甜味保湿剂和调味品，对可湿性粉剂吸烟的成瘾性、毒性、风味感知和吸引力。 这项拟议的研究使用了交叉人体试验，一种操纵的可湿性粉剂烟草制品，一项经过验证的研究 等级水管和尖端分析化学和心理社会仪器系统 调查甜味保湿剂浓度和调味品对吸引力、膨化行为和 可湿性粉剂烟草吸烟的毒性。拟议研究的目的是获得可靠的科学数据，以便为 制定可能的监管行动，如识别和建立基于证据的产品 标准，或可湿性粉剂烟草中添加剂的最大阈值，不得超过 在美国销售和分销的产品。本研究将通过以下方式解决RFA-OD-15-005问题3和4 量化可湿性粉剂烟草添加剂，如保湿剂和调味剂，对人体膨化的影响 在主流可湿性粉剂烟草烟雾中的行为和HPHC水平，以解决这些重要的数据差距。

Project Summary Waterpipe (WP) tobacco smoking has surpassed cigarette smoking and now rivals the electronic cigarette as the most popular tobacco product class in the US among youth. This may be due to the availability of sweet, fruit- and candy-flavored tobaccos that make inhaling tobacco smoke more appealing. It is not clear what is most important in terms of increasing appeal: the smoker's perception of sweetness, or flavor, or both. WP tobacco is unique because of the amounts and identities of its additives and the way that it is smoked. The flavorings and high levels of sweet humectants produce harmful and potentially harmful constituents in the smoke, and are thought to contribute to the direct and indirect harm experienced by users. To define the effects of specific chemical content with respect to sweet perception and likability among users, WP tobacco that differs only in the variables of interest must be used. There is no set of commercially available tobacco brands for which this is true, and thus we propose to manipulate commercial products to properly isolate the important variables. There is an existing data gap surrounding the influence of WP tobacco additives, i.e., sweet humectants and flavorings, on the addictiveness, toxicity, flavor perceptions and appeal of WP smoking. The proposed study uses a crossover human trial, a manipulated WP tobacco prodcut, a validated research grade waterpipe and cutting edge analytical chemistry and psychosocial instruments to systematically investigate the effects of sweet humectant concentration and flavorings on the appeal, puffing behavior, and toxicity of WP tobacco smoking. The purpose of the proposed study is to acquire sound scientific data to inform the development of possible regulatory actions such as identifying and establishing evidenced-based product standards, or maximum thresholds of additives in WP tobacco that must not be exceeded in order for the product to be sold and distributed in the US. This study will address RFA-OD-15-005 questions 3 and 4 by quantifying the impact of WP tobacco additives, such as humectants and flavorants, on human puffing behaviors and HPHC levels in mainstream WP tobacco smoke to address these important data gaps.