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Waterpipe tobacco additives and their effect on human puffing behavior, toxicant exposures, pulmonary function, and appeal

水烟烟草添加剂及其对人类吸烟行为、毒物暴露、肺功能和吸引力的影响

基本信息

批准号：
10264147
负责人：
Marielle Cavanaugh Brinkman
金额：
$ 44.08万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10264147
关键词：
Acute Address Affect Analytical Chemistry Area Automobile Driving Behavior Biological Markers Carcinogens Chemicals Chemistry Child Cigar Cigarette Data Development Engineering Exposure to Food Form Perception Friends Fructose Furans Glucose Glycerol Health High School Student Human Individual Ingestion Inhalation Laboratories Link Lung Mainstreaming Masks Measures Nicotine Participant Perception Preparation Prevalence Regimen Regulation Reporting Research Sensory Single-Blind Study Smoke Smoker Smoking Standardization Techniques Time Tobacco Tobacco smoke Tobacco smoking behavior Tobacco use Toxic effect Toxicant exposure Weight Youth addiction cigarette smoke cigarette smoking evidence base experience exposed human population high school hookah human study instrument interest junior high school psychosocial pulmonary function risk perception satisfaction smoke inhalation sound sugar sweet taste perception tobacco products toxicant university student uptake young adult

项目摘要

Abstract In the 30 years since its introduction, sweetened waterpipe (WP) tobacco, or “ma’assel”, is now smoked by over half a million middle and high school children and 1.2M young adults in the U.S. This may be due to the sweet additives that comprise up to 70% of the weight of the tobacco and make inhaling WP tobacco smoke more appealing and easier for first-time users. WP tobacco is unique in that the ratio of sweet additives to nicotine is significantly higher than for any other tobacco product, making WP the perfect “starter product” for nicotine initiation. It is largely misperceived that smoking tobacco with a WP or hookah is a less harmful form of tobacco use. In fact, the high levels of sweet additives transfer nicotine efficiently and produce harmful and potentially harmful constituents in the smoke, contributing to the direct and indirect harm experienced by users. To define the effects of WP tobacco’s primary chemical additives with respect to sweet perception, appeal, toxicant exposure, addictiveness, harm and health risk perceptions, and lung function among WP users, WP tobacco that differs only in the additives of interest must be used. There is no set of commercially available tobacco brands for which this is true, and thus our study will manipulate commercial products to properly isolate the important variables. There is an existing data gap surrounding the influence of WP tobacco’s primary additives, all of which are sweet tasting compounds, on the addictiveness, toxicity, flavor perceptions, appeal and perceived harm of WP smoking. The proposed study uses a crossover single-blind human trial of dyads, a manipulated WP tobacco product, a validated dual-hose research-grade WP, cutting edge psychosocial instruments and analytical chemistry techniques to assess human exposure to systematically investigate the effects of sweet additives on the appeal, puffing behavior, and toxicity of WP tobacco smoking. Currently there are no regulations governing WP additives. The purpose of the proposed study is to acquire sound scientific data to inform the development of evidenced-based product standards, or limits to additives in WP tobacco that must not be exceeded in order for the product to be sold and distributed in the U.S. The proposed study will address RFA-OD-19-028’s Scientific Interest Areas of: Chemistry and Engineering, Toxicity, and Behavior and Addiction, in that it will determine how specific WP tobacco additives affect users puffing behavior, liking, harm perceptions, the quantities of toxicants they inhale and take up in the body, and acute pulmonary affects from WP tobacco smoking.

摘要