Smoking Machine Adaptor Design Project for ENDS, Cigars, and Heated Tobacco Products (UC2)

摘要 吸烟机适配器设计项目的目的是开发一个标准化和有效的 适配器或适配器系列，用于连接到现有的吸烟和蒸汽机，以确保准确性 电子材料的物理和化学性质的研究所获得的科学数据的可靠性 尼古丁输送系统（ENDS）、雪茄和加热烟草产品（HTPs）。同样重要的是， 将制定一套协议，用于生成和收集这四种产品的主流产量数据 类型对于拟议的研究工作，俄亥俄州州立大学（主承包商）将密切合作 与食品和药物管理局的烟草制品中心（CTP），以及我们拟议的团队合作， 成员，包括我们的颗粒和气溶胶表征实验室，疾病控制中心和 预防烟草制品实验室（CDC-TPL）;我们的吸烟和蒸汽机行业合作伙伴， Cerulean和前Borgwaldt KC USA直线吸烟机设计实施工程师Jeremy 琼斯，总统，生产更好。该项目由四个主要阶段组成：1）可行性，2）原型 设计和测试，3）适配器确认，以及4）持续的利益相关者支持。一旦验证了 适配器完成后，我们的团队将负责制造，销售和持续的设备支持， 包括在项目的最后阶段和CTP之后对USMA进行持续的设计改进 赞助结束了。该项目将通过确保利益相关者能够 生成准确的科学数据并减少测量变异性，以帮助填补当前的科学空白 关于ENDS、雪茄和HTPs的化学和物理性质。这些数据将有助于FDA 使命是保护美国人免受烟草相关死亡和疾病的影响， 教育公众，特别是年轻人，了解烟草产品及其使用对健康的危害。 自己和他人。

ABSTRACT The purpose of the smoking machine adaptor design project is to develop a standardized and validated adaptor, or family of adaptors, for attachment to existing smoking and vaping machines to ensure the accuracy and reliability of scientific data obtained from the study of the physical and chemical properties of electronic nicotine delivery systems (ENDS), cigars, and heated tobacco products (HTPs). Equally important, the project will produce a set of protocols for the generation and collection of mainstream yield data for these four product types. For the proposed research efforts, the Ohio State University (prime contractor) will collaborate closely with the Food and Drug Administration’s Center for Tobacco Products (CTP), and with our proposed team members, including our Particle and Aerosol Characterization Laboratory, the Centers for Disease Control and Prevention Tobacco Products Laboratory (CDC-TPL); our smoking and vaping machine industry partner, Cerulean; and former Borgwaldt KC USA linear smoking machine design implementation engineer, Jeremy Jones, President, Produced Better. The project is comprised of four main phases: 1) Feasibility, 2) Prototype Design and Testing, 3) Adaptor Validation, and 4) Continued Stakeholder Support. Once the validation of the adaptors is complete, our team will be responsible for the manufacture, sale, and continued device support, including continuous design improvement, of the USMA in the final phase of the project and after CTP sponsorship has concluded. The project will provide a public benefit by ensuring that stakeholders can generate accurate scientific data and reduce measurement variability to help fill current scientific gaps regarding the chemical and physical properties of ENDS, cigars, and HTPs. These data will assist FDA in their mission to protect Americans from tobacco-related death and disease by regulating tobacco products and by educating the public, especially young people, about tobacco products and the dangers their use poses to themselves and others.