Smoking Machine Adaptor Design Project for ENDS, Cigars, and Heated Tobacco Products (UC2)

摘要 吸烟机适配器设计项目的目的是开发一种标准化和经验证的 转接器，或转接器系列，用于连接现有的吸烟机和蒸发机，以确保准确性 从电子材料的物理化学性质的研究中获得的科学数据的可靠性 尼古丁输送系统(完)、雪茄和加热烟草产品(HTP)。同样重要的是，该项目 将制定一套协议，用于生成和收集这四种产品的主流产量数据 类型。对于拟议的研究工作，俄亥俄州立大学(主承包商)将密切合作 与食品和药物管理局烟草产品中心(CTP)以及我们建议的团队合作 成员，包括我们的颗粒物和气溶胶表征实验室，疾病控制中心和 预防烟草产品实验室(CDC-TPL)；我们的吸烟和蒸发机行业合作伙伴， 前Borgwaldt KC USA直线吸烟机设计实施工程师Jeremy 总裁琼斯制作得更好。该项目由四个主要阶段组成：1)可行性，2)原型 设计和测试，3)适配器验证，以及4)持续的利益相关者支持。一旦验证了 适配器完成后，我们的团队将负责制造、销售和持续的设备支持， 包括在项目最后阶段和CTP之后对USMA进行持续设计改进 赞助商已经结束。该项目将通过确保利益相关者能够 生成准确的科学数据并降低测量变异性，以帮助填补当前的科学空白 关于END、雪茄和HTP的化学和物理性质。这些数据将有助于FDA 通过管理烟草产品和通过以下方式保护美国人免受与烟草有关的死亡和疾病的使命 教育公众，特别是年轻人，了解烟草产品及其使用带来的危险 他们自己和其他人。

ABSTRACT The purpose of the smoking machine adaptor design project is to develop a standardized and validated adaptor, or family of adaptors, for attachment to existing smoking and vaping machines to ensure the accuracy and reliability of scientific data obtained from the study of the physical and chemical properties of electronic nicotine delivery systems (ENDS), cigars, and heated tobacco products (HTPs). Equally important, the project will produce a set of protocols for the generation and collection of mainstream yield data for these four product types. For the proposed research efforts, the Ohio State University (prime contractor) will collaborate closely with the Food and Drug Administration’s Center for Tobacco Products (CTP), and with our proposed team members, including our Particle and Aerosol Characterization Laboratory, the Centers for Disease Control and Prevention Tobacco Products Laboratory (CDC-TPL); our smoking and vaping machine industry partner, Cerulean; and former Borgwaldt KC USA linear smoking machine design implementation engineer, Jeremy Jones, President, Produced Better. The project is comprised of four main phases: 1) Feasibility, 2) Prototype Design and Testing, 3) Adaptor Validation, and 4) Continued Stakeholder Support. Once the validation of the adaptors is complete, our team will be responsible for the manufacture, sale, and continued device support, including continuous design improvement, of the USMA in the final phase of the project and after CTP sponsorship has concluded. The project will provide a public benefit by ensuring that stakeholders can generate accurate scientific data and reduce measurement variability to help fill current scientific gaps regarding the chemical and physical properties of ENDS, cigars, and HTPs. These data will assist FDA in their mission to protect Americans from tobacco-related death and disease by regulating tobacco products and by educating the public, especially young people, about tobacco products and the dangers their use poses to themselves and others.