课题基金 / 基金详情

Screening the Ribosome for New Target Sites

Screening the Ribosome for New Target Sites
筛选核糖体的新靶位点
批准号:
9140721
负责人:
DEV PRIYA ARYA
金额:
$32.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-07-13 至 2018-06-30

项目摘要

项目成果

DEV PRIYA ARYA的其他基金

相似基金

相关文献

中文摘要
翻译

英文摘要
 DESCRIPTION (provided by applicant): Nucleic acids are avenues for drug design, both as therapeutics and as targets. Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds. Targeting specific RNA, such as rRNA which are involved in proliferation and survival of bacteria is a promising approach. We are developing fast and low cost methods to screen sequence-specific small molecules for novel anti- ribosomal activities. We will construct sequence-specific ribosomal targeting oligomers as antibacterials, that can be effectively delivered inside the cell. Complexes between ribosomal components will be exploited as targets for small molecule drug libraries that- inactivate the ribosome, stopping bacterial protein synthesis and causing bacterial death. NUBADs unique experimental approaches and technologies will allow us to target ribosomal regions not previously explored for susceptibility against anti-bacterial agents. This work addresses an important world health issue, antimicrobial resistance, and presents creative steps towards a novel solution to this problem. The work proposed here, a multidisciplinary effort encompassing solid-phase organic synthesis, oligonucleotide delivery, RNA targeted screening and antibacterial studies, describes the development of sequence-specific cell permeable binders of rRNA as antibacterial therapeutics. The success of the proposed work would be a significant addition to currently available ribosome-specific approaches in antibacterial therapy. We propose using a small rRNA target sequences to design conjugates that can be employed to inhibit bacterial growth, opening possibilities for developing sequence-specific RNA targeted therapeutics.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Development of peptide nucleic acid antibiotics
  • 批准号:
    10347347
  • 项目类别:
  • 资助金额:
    $99.96万
  • 财政年份:
    2021
  • 负责人:
    DEV PRIYA ARYA
  • 依托单位:
Delivery of chemically modified PNA oligomers
  • 批准号:
    10006671
  • 项目类别:
  • 资助金额:
    $30.0万
  • 财政年份:
    2020
  • 负责人:
    DEV PRIYA ARYA
  • 依托单位:
Aminoglycosides with reduced ototoxicity
  • 批准号:
    10156973
  • 项目类别:
  • 资助金额:
    $100.0万
  • 财政年份:
    2020
  • 负责人:
    DEV PRIYA ARYA
  • 依托单位:
Aminoglycosides with reduced ototoxicity
  • 批准号:
    10377538
  • 项目类别:
  • 资助金额:
    $99.97万
  • 财政年份:
    2020
  • 负责人:
    DEV PRIYA ARYA
  • 依托单位:
海外基金