Enhancing the NMR Characterization of Amino Sugars

增强氨基糖的 NMR 表征

• 批准号: 1213845
• 负责人: Cynthia Larive
• 金额: $ 46.63万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213845&HistoricalAwards=false
• 关键词: Enhancing; NMR; Characterization; Amino; Sugars

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Cynthia Larive of the University of California - Riverside and her graduate student researchers will be supported to develop instrumentation for coupling online microcoil nuclear magnetic resonance (NMR) detection with electrophoretic separation. The group will investigate the structure of the biologically important glycosaminoglycan (GAG) carbohydrate with two-dimensional NMR methods.Nuclear magnetic resonance spectroscopy is an important physical chemical method that gives precise chemical and structural information. The methods that Prof. Larive and her student researchers will develop will enable scientists to determine the solution-phase structures of some important carbohydrates. The work has the potential to provide important information on the biosynthesis of these carbohydrates, as well as guiding scientists in the design of new drugs and measurements of purity of related GAG-based pharmaceuticals (e.g. heparin). The graduate students working on this project will gain useful experience in developing cutting-edge analytical NMR experiments. As part of this work, Prof. Larive will continue her strong efforts at encouraging students from underrepresented groups to pursue careers in the sciences.

该奖项由化学系化学测量和成像项目资助，加州大学滨江分校的Cynthia Larive教授和她的研究生研究人员将获得支持，开发用于将在线微线圈核磁共振（NMR）检测与电泳分离相结合的仪器。 该小组将利用二维NMR方法研究生物学上重要的糖胺聚糖（GAG）碳水化合物的结构。核磁共振光谱是一种重要的物理化学方法，可以提供精确的化学和结构信息。 拉里夫教授和她的学生研究人员将开发的方法将使科学家能够确定一些重要碳水化合物的溶液相结构。这项工作有可能提供有关这些碳水化合物生物合成的重要信息，并指导科学家设计新药和测量相关基于GAG的药物（例如肝素）的纯度。 从事该项目的研究生将获得开发尖端分析NMR实验的有用经验。 作为这项工作的一部分，拉里夫教授将继续努力鼓励来自代表性不足群体的学生从事科学事业。