Pathogenic flaviviruses: molecular mechanisms of disease, host response and vaccines

致病性黄病毒：疾病、宿主反应和疫苗的分子机制

• 批准号: nhmrc : 1059794
• 负责人: Prof Alexander Khromykh
• 金额: $ 46.49万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathogenic-flaviviruses-molecular-response-vaccines/454784
• 关键词: Pathogenic; flaviviruses; molecular; mechanisms; disease

The application is aimed at advancing our understanding of the viral and host processes determining outcome of infection with pathogenic flaviviruses (i.e. West Nile virus) to the level allowing most comprehensive design of effective vaccines and anti-viral drugs. One of the aims is also to develop novel viral delivery vectors for cancer therapy based on self-replicating RNA of an attenuated Australian strain of West Nile virus, Kunjin.

该申请旨在推进我们对决定致病性黄病毒（即西尼罗河病毒）感染结果的病毒和宿主过程的理解，以达到最全面设计有效疫苗和抗病毒药物的水平。其中一个目标也是开发用于癌症治疗的新型病毒递送载体，其基于西尼罗河病毒Kunjin的减毒澳大利亚株的自我复制RNA。