Host genes controlling Flavivirus infection: new insights and application for developing highly effective Kunjin replicon-based Ebola vaccine
Host genes controlling Flavivirus infection: new insights and application for developing highly effective Kunjin replicon-based Ebola vaccine
批准号:
nhmrc : 1102421
负责人:
Prof Alexander Khromykh
金额:
$50.62万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The applications is aimed at identifying new host genes controlling infection with West Nile virus and other medically important flaviviruses such as dengue and Japanese encephalitis. For this, we will use novel in vivo RNAi screening approach with virus libraries encoding artificial microRNAs (amirs) targeting whole mouse genome. We will then apply amiR technology to produce highly effective Kujniin replicon-based Ebola vaccine candidate that has shown promising results in trails in primates.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
From shape to function: how structured RNA defines insect flaviviruses
-
批准号:DP240102506
-
项目类别:Discovery Projects
-
资助金额:$44.16万
-
财政年份:2024
-
负责人:Prof Alexander Khromykh
-
依托单位:
Noncoding RNAs of insect-specific flaviviruses: biogenesis and functions
-
批准号:DP190103304
-
项目类别:Discovery Projects
-
资助金额:$30.5万
-
财政年份:2019
-
负责人:Prof Alexander Khromykh
-
依托单位:
The role of noncoding viral RNAs in flavivirus infection and exosomal signalling
-
批准号:nhmrc : GNT1127916
-
项目类别:Project Grants
-
资助金额:$68.34万
-
财政年份:2017
-
负责人:Prof Alexander Khromykh
-
依托单位:
The role of noncoding viral RNAs in flavivirus infection and exosomal signalling
-
批准号:nhmrc : 1127916
-
项目类别:Project Grants
-
资助金额:$46.64万
-
财政年份:2017
-
负责人:Prof Alexander Khromykh
-
依托单位:
Host genes controlling Flavivirus infection: new insights and application for developing highly effective Kunjin replicon-based Ebola vaccine
-
批准号:nhmrc : GNT1102421
-
项目类别:Project Grants
-
资助金额:$73.7万
-
财政年份:2016
-
负责人:Prof Alexander Khromykh
-
依托单位:
Pathogenic flaviviruses: molecular mechanisms of disease, host response and vaccines
-
批准号:nhmrc : 1059794
-
项目类别:Research Fellowships
-
资助金额:$46.49万
-
财政年份:2014
-
负责人:Prof Alexander Khromykh
-
依托单位:
Pathogenic flaviviruses: molecular mechanisms of disease, host response, and vaccines
-
批准号:nhmrc : GNT1059794
-
项目类别:Research Fellowships
-
资助金额:$66.45万
-
财政年份:2014
-
负责人:Prof Alexander Khromykh
-
依托单位:
Wolbachia and West Nile virus in mosquitoes: friends or foes?
-
批准号:nhmrc : 1062983
-
项目类别:Project Grants
-
资助金额:$37.41万
-
财政年份:2014
-
负责人:Prof Alexander Khromykh
-
依托单位:
The role of noncoding subgenomic flavivirus RNA in virus-host interactions
-
批准号:nhmrc : 1045080
-
项目类别:Project Grants
-
资助金额:$41.64万
-
财政年份:2013
-
负责人:Prof Alexander Khromykh
-
依托单位:
Role of flavivirus-encoded small regulatory RNAs in virus-mosquito vector interactions
-
批准号:nhmrc : 1027110
-
项目类别:Project Grants
-
资助金额:$36.49万
-
财政年份:2012
-
负责人:Prof Alexander Khromykh
-
依托单位:
A functional interaction between domains of the flavivirus NS5 protein presents a new target for antiviral therapy
-
批准号:nhmrc : 631520
-
项目类别:NHMRC Project Grants
-
资助金额:$33.53万
-
财政年份:2010
-
负责人:Prof Alexander Khromykh
-
依托单位:
Uncoupled Research Fellowship
-
批准号:nhmrc : 569537
-
项目类别:NHMRC Research Fellowships
-
资助金额:$38.72万
-
财政年份:2009
-
负责人:Prof Alexander Khromykh
-
依托单位:
Virulence determinants of encephalitic flaviviruses
-
批准号:nhmrc : 456126
-
项目类别:NHMRC Project Grants
-
资助金额:$30.38万
-
财政年份:2008
-
负责人:Prof Alexander Khromykh
-
依托单位:
The West Nile viral protease, NS3: a target for antiviral drug and vaccine design
-
批准号:nhmrc : 351594
-
项目类别:NHMRC Project Grants
-
资助金额:$15.37万
-
财政年份:2005
-
负责人:Prof Alexander Khromykh
-
依托单位:
Kunjin replicons for gene therapy and protein manufacture
-
批准号:nhmrc : 241967
-
项目类别:NHMRC Development Grants
-
资助金额:$20.67万
-
财政年份:2003
-
负责人:Prof Alexander Khromykh
-
依托单位:
Molecular analyses of flavivirus RNA replication, encapsidation, and complementation
-
批准号:nhmrc : 142983
-
项目类别:NHMRC Project Grants
-
资助金额:$40.18万
-
财政年份:2001
-
负责人:Prof Alexander Khromykh
-
依托单位:
Kunjin virus replicon-based vaccine vectors: new developments and applications
-
批准号:nhmrc : 142911
-
项目类别:NHMRC Project Grants
-
资助金额:$15.14万
-
财政年份:2001
-
负责人:Prof Alexander Khromykh
-
依托单位:
Molecular mechanisms of flavivirus rna replication
-
批准号:nhmrc : 981442
-
项目类别:NHMRC Project Grants
-
资助金额:$33.37万
-
财政年份:1998
-
负责人:Prof Alexander Khromykh
-
依托单位:
国内基金
海外基金
登录
查看更多内容
精神分裂症脑网络异常的影像遗传学研究
-
批准号:81000582
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2010
-
负责人:刘冰
-
依托单位:
孤独症全基因组关联第二阶段研究
-
批准号:81071110
-
项目类别:面上项目
-
资助金额:32.0万元
-
批准年份:2010
-
负责人:王力芳
-
依托单位:
孤独症与突触发育相关候选基因的关联研究
-
批准号:30870897
-
项目类别:面上项目
-
资助金额:50.0万元
-
批准年份:2008
-
负责人:张岱
-
依托单位:
用dsDNA微阵列筛选NF-κB DNA靶点及靶基因
-
批准号:60871014
-
项目类别:面上项目
-
资助金额:35.0万元
-
批准年份:2008
-
负责人:王进科
-
依托单位:
大鱼际掌纹特应征与5个哮喘易感基因单核苷酸多态性的关联分析
-
批准号:30873315
-
项目类别:面上项目
-
资助金额:31.0万元
-
批准年份:2008
-
负责人:周兆山
-
依托单位: