Life Science and Biomedical technology Research center at NSLS-II LSBR

项目描述（由申请人提供）：该项目将为生命科学研究界开发一套世界领先的实验设施。随着大分子晶体学（MX）和x射线散射的重点，还将有相关的MX和光谱学的用户程序，以及生物材料中金属的荧光成像的用户程序。NSLS-II的非凡亮度将提供前所未有的小、亮、准直良好的x射线束。为了充分利用这些特性，将格外注意从NSLS-II光束中提供最优质的晶体衍射和x射线散射数据，并实现高水平的自动化。将安装多个实验模式用于x射线散射，以研究溶液、膜和组织。我们期待这个项目取得巨大成功，部分原因在于从波士顿到华盛顿的400英里长的走廊上有杰出的生命科学研究人员，这些研究人员都在BNL的驾车距离之内，以及在NSLS的生命周期中为这个社区提供的结构生物学生产力的坚实记录。

DESCRIPTION (provided by applicant): The project will develop a world-leading suite of experimental facilities for the life-science research community. With the focus on macromolecular crystallography (MX) and x-ray scattering, there will also be user programs in correlated MX and optical spectroscopy, and one in fluorescence imaging of metals in biological materials. The extraordinary brightness of NSLS-II will provide unprecedentedly small, bright, and well-collimated x-ray beams. To exploit these qualities, extra care will be exerted to provide the best quality crystal-diffraction and x-ray scattering data from the NSLS-II beams, and high levels of automation. Multiple experimental modes will be installed for x-ray scattering to investigate solutions, membranes, and tissues. We expect high success of the project, owed in part to the remarkable community of life-science researchers in the 400 mile-long corridor from Boston to Washington, all within driving distance of BNL, and to the solid record of productivity in structural biology having been provided this community during the lifetime of the NSLS.