DEVELOP NSLS-II BEAMLINES FOR MACROMOLECULAR CRYSTALLOGRAPHY

开发用于高分子晶体学的 NSLS-II 束线

• 批准号: 8363415
• 负责人: ROBERT M SWEET
• 金额: $ 5.75万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363415
• 关键词: Address; Advisory Committees; Automation; Biological Sciences; Biology; Calculi; Caliber; Crystallography; Floor; Fruit; Funding; Future; Grant; Light; National Center for Research Resources; Optics; Phase; Principal Investigator; Progress Reports; Reporting; Research; Research Infrastructure; Resources; Source; Specific qualifier value; Spectrum Analysis; Structure; Synchrotrons; Time; United States National Institutes of Health; Universities; Work; base; beamline; cost; design; meetings; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives The objectives stated in the recent renewal proposal are these: create a draft plan for the final build out of NSLS-II for life sciences, create a conceptual design for a Phase-1 buildup of macromolecular crystallography beamlines at NSLS-II, establish advisory committees, specify details, of floor layouts for two or three adjacent sectors, plan the timing of the move of NSLS beamline components to the three-pole wigglers at NSLS-II, and specify a Lab and Office Building to serve a Biology Village on the NSLS-II floor. Although these objectives were warmly endorsed by the review panel, we were not directly funded to pursue any of these objectives. Nevertheless, with limited resources available to us, we commenced effort to address a subset of these objectives and report them here because of their importance to the integrated project. Results -- Three proposals were approved by the NSLS-II SAC: Two were for a canted-pair of undulators. FMX would produce a beam as small as one micron diameter to serve the most difficult problems https://www.px.nsls.bnl.gov/for_mxbat/BDP_2010_FMX_21.pdf. AMX would be highly accessible and efficient, having top quality automation. A third approved beamline was SM3, to employ a three-pole wiggler source and to provide correlated MX and optical spectroscopy. The approved proposals were prepared by a group, calling ourselves the MX Working Group, which met regularly over the previous two years, working to design especially undulator beamlines. A nearly complete roster includes: Lonny Berman, NSLS and NSLS-II; Robert Sweet, Dieter Schneider, Howard Robinson, Allen Orville, Alexei Soares, Annie Heroux, Deborah Stoner-Ma, BNL Biology; Mark Chance, Michael Sullivan, Wuxian Shi, Case Western Reserve; Wayne Hendrickson, Columbia University and NSLS-II; Marc Allaire, Vivian Stojanoff, Jean Jakoncic, Kun Qian, NSLS; Qun Liu, John Schwanof, Randy Abramowitz; Columbia Univ. Plans  A full time-line of our efforts are the the full Research Progress report. Now we wait. We have made clear that we in the PXRR are prepared to do whatever is necessary to bring these plans to fruition. We also work with The Working Group and others to prepare a scientific case for BER/DOE support of future beamlines. We see this as the next best possibility for finding funding for the approved MX/Spectroscopy beamline known as SM3. Significance  Our longstanding efforts to create a life-science presence at NSLS-II are bearing fruit. The new facilities there will be the best in the world for all x-ray-based studies of biomolecular structure.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目标 最近更新提案中所述的目标如下：为生命科学 NSLS-II 的最终建设制定计划草案，为 NSLS-II 高分子晶体学光束线的第一阶段建设制定概念设计，建立咨询委员会，指定两个或三个相邻区域的楼层布局细节，规划 NSLS 光束线组件移动到 NSLS-II 的时间。 NSLS-II 的三极摇摆器，并指定实验室和办公楼为 NSLS-II 层的生物村提供服务。尽管这些目标得到了审查小组的热烈支持，但我们并没有直接获得资金来实现这些目标。 尽管如此，由于我们可用的资源有限，我们开始努力实现这些目标的一部分，并在此报告它们，因为它们对综合项目很重要。 结果 - NSLS-II SAC 批准了三项提案： 两项被批准 对于一对倾斜的波荡器。 FMX 将产生直径小至一微米的光束来解决最困难的问题 https://www.px.nsls.bnl.gov/for_mxbat/BDP_2010_FMX_21.pdf。 AMX 将具有高度可访问性和高效性，并具有最高质量的自动化。第三条批准的光束线是 SM3，采用三极摆动源并提供相关的 MX 和光谱。 批准的提案是由一个自称为 MX 工作组的小组准备的，该小组在过去两年定期举行会议，致力于设计特别的波荡器光束线。几乎完整的名单包括：Lonny Berman、NSLS 和 NSLS-II； Robert Sweet、Dieter Schneider、Howard Robinson、Allen Orville、Alexei Soares、Annie Heroux、Deborah Stoner-Ma、BNL Biology；马克·钱斯 (Mark Chance)、迈克尔·沙利文 (Michael Sullivan)、施无贤 (Wuxian Shi)，凯斯西储大学； Wayne Hendrickson，哥伦比亚大学和 NSLS-II； Marc Allaire、Vivian Stojanoff、Jean Jakoncic、钱坤，NSLS；刘群、约翰·施瓦诺夫、兰迪·阿布拉莫维茨；哥伦比亚大学 计划 我们努力的完整时间表是完整的研究进展报告。现在我们等待。我们已经明确表示，我们 PXRR 准备采取一切必要措施来实现这些计划。我们还与工作组和其他人合作，为未来光束线的 BER/DOE 支持准备科学案例。我们认为这是为被批准的 MX/光谱光束线（称为 SM3）寻找资金的下一个最佳可能性。 意义 我们长期以来为在 NSLS-II 建立生命科学领域所做的努力正在取得成果。 那里的新设施将是世界上最好的所有基于 X 射线的生物分子结构研究设施。