DEVELOP NSLS-II BEAMLINES FOR MACROMOLECULAR CRYSTALLOGRAPHY

开发用于高分子晶体学的 NSLS-II 束线

• 批准号: 8363415
• 负责人: ROBERT M SWEET
• 金额: $ 5.75万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363415
• 关键词: Address; Advisory Committees; Automation; Biological Sciences; Biology; Calculi; Caliber; Crystallography; Floor; Fruit; Funding; Future; Grant; Light; National Center for Research Resources; Optics; Phase; Principal Investigator; Progress Reports; Reporting; Research; Research Infrastructure; Resources; Source; Specific qualifier value; Spectrum Analysis; Structure; Synchrotrons; Time; United States National Institutes of Health; Universities; Work; base; beamline; cost; design; meetings; working group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objectives The objectives stated in the recent renewal proposal are these: create a draft plan for the final build out of NSLS-II for life sciences, create a conceptual design for a Phase-1 buildup of macromolecular crystallography beamlines at NSLS-II, establish advisory committees, specify details, of floor layouts for two or three adjacent sectors, plan the timing of the move of NSLS beamline components to the three-pole wigglers at NSLS-II, and specify a Lab and Office Building to serve a Biology Village on the NSLS-II floor. Although these objectives were warmly endorsed by the review panel, we were not directly funded to pursue any of these objectives. Nevertheless, with limited resources available to us, we commenced effort to address a subset of these objectives and report them here because of their importance to the integrated project. Results -- Three proposals were approved by the NSLS-II SAC: Two were for a canted-pair of undulators. FMX would produce a beam as small as one micron diameter to serve the most difficult problems https://www.px.nsls.bnl.gov/for_mxbat/BDP_2010_FMX_21.pdf. AMX would be highly accessible and efficient, having top quality automation. A third approved beamline was SM3, to employ a three-pole wiggler source and to provide correlated MX and optical spectroscopy. The approved proposals were prepared by a group, calling ourselves the MX Working Group, which met regularly over the previous two years, working to design especially undulator beamlines. A nearly complete roster includes: Lonny Berman, NSLS and NSLS-II; Robert Sweet, Dieter Schneider, Howard Robinson, Allen Orville, Alexei Soares, Annie Heroux, Deborah Stoner-Ma, BNL Biology; Mark Chance, Michael Sullivan, Wuxian Shi, Case Western Reserve; Wayne Hendrickson, Columbia University and NSLS-II; Marc Allaire, Vivian Stojanoff, Jean Jakoncic, Kun Qian, NSLS; Qun Liu, John Schwanof, Randy Abramowitz; Columbia Univ. Plans  A full time-line of our efforts are the the full Research Progress report. Now we wait. We have made clear that we in the PXRR are prepared to do whatever is necessary to bring these plans to fruition. We also work with The Working Group and others to prepare a scientific case for BER/DOE support of future beamlines. We see this as the next best possibility for finding funding for the approved MX/Spectroscopy beamline known as SM3. Significance  Our longstanding efforts to create a life-science presence at NSLS-II are bearing fruit. The new facilities there will be the best in the world for all x-ray-based studies of biomolecular structure.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 目标 在最近的更新建议中所述的目标是：为NSLS-II的生命科学最终建设制定计划草案，为NSLS-II的大分子晶体学光束线的第一阶段建设制定概念设计，建立咨询委员会，指定两个或三个相邻部门的楼层布局细节，计划将NSLS光束线组件移到NSLS-II的三极摇摆器的时间，并指定一个实验室和办公楼，为NSLS-II楼层的生物村服务。虽然这些目标得到了审查小组的热烈赞同，但我们没有直接获得资金来实现这些目标。 尽管如此，由于我们可用的资源有限，我们开始努力解决这些目标的一个子集，并在这里报告，因为它们对综合项目的重要性。 结果-NSLS-II SAC批准了三项提案： 一对倾斜的波浪鞋 FMX将产生一个小到一微米直径的光束，以解决最困难的问题。https://www.px.nsls.bnl.gov/for_mxbat/BDP_2010_FMX_21.pdf AMX将是高度可访问和高效的，具有高质量的自动化。第三个被批准的光束线是SM 3，采用三极摇摆器源，并提供相关的MX和光学光谱。 批准的建议书是由一个称为MX工作组的小组准备的，该小组在过去两年中定期开会，专门设计波荡器光束线。一个几乎完整的名册包括：朗尼伯曼，国家科学实验室和国家科学实验室第二阶段;罗伯特斯威特，迪特尔施奈德，霍华德罗宾逊，艾伦奥维尔，阿列克谢苏亚雷斯，安妮赫鲁，德博拉斯托纳马，生物学BNL;马克机会，迈克尔沙利文，石武贤，凯斯西储;韦恩亨德里克森，哥伦比亚大学和国家科学实验室第二阶段;马克阿莱尔，维维安斯托扬诺夫，让雅孔西奇，钱坤，国家科学实验室;刘群，约翰施瓦诺夫，兰迪阿布拉莫维茨;哥伦比亚大学 计划  我们努力的完整时间线是完整的研究进展报告。现在我们等着我们已经明确表示，我们在PXRR准备做任何必要的，使这些计划的成果。我们还与工作组和其他人合作，为BER/DOE支持未来光束线准备科学案例。我们认为这是为已批准的MX/Spectroscopy光束线（称为SM 3）寻找资金的下一个最佳可能性。 意义  我们长期以来为在NSLS-II创建生命科学存在所做的努力正在取得成果。 那里的新设施将是世界上最好的，用于所有基于x射线的生物分子结构研究。