MACROMOLECULAR STRUCTURE DETERMINATION - GENERAL USERS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This subproject consists of a group of projects for which either abstracts were not available, or the total use was less than 0.1% of grant dollars, carried out by investigators who each consumed beamtime for the collection of x-ray diffraction data for 3-dimensional crystal structure solving. The investigators included in the list of personnel are the ones not identified with any other subproject. The investigators/subprojects for which their total use was less than 0.1% of grant dollars include the following: Roy Mariuzza Crystal structure of the natural killer cell receptor 2B4 in complex with CD48 Jurgen Sygusch Structural basis for substrate recognition in class I Tagatose-1,6-Bisphosphate Aldolase Jonathan Goldberg Structure determination of the Sec 13/ Sec 31 complex Roy Mariuzza Structure of bacterial superantigens: SEG-Vb8.2 Catherine Lawson CAP-AlphaCTD-DNA (*cterm domain of alpha subunit of RNA polymerase) Fred Guengerich DNA polymerase Dpo4 Evette Radisky Human mesotrypsin S195A - complex with BPTI - crystal screen condition #32 Zongchao Jia E. coli tyrosine kinase Xiangpeng Kong Structures of priming and recombination complexes Elias Lolis CXCL12 (Stromal Cell-derived factor 1-alpha) in complex with heparin Susan Buchanan Pesticin/yersiniabactin receptor protein fyuA Timothy Springer Integrin ectodomain Ya Ha Structural study of human amyloid precursor protein Ann Stock Structural analysis of response regulator proteins Radha Devi Structural studies on Gi proteins Nicholas Silvaggi Human phosphomannomutase 1 Christopher Hill UROD Saurav Misra Bag2-Bag domain Jianyong Li Aedes alanine glyoxylate aminotransferase Mingdong Huang Urokinase-vitronectin complex Roy Mariuzza Structure and Function of Natural Killer Cell Receptors: Ly49L4 Full Length Nicholas Silvaggi Tandem Lanthanide Binding Tag-Labeled Alkaline Phosphatase Caroline Kisker Y-family DNA polymerase Christopher Hill Structural Studies of HIV-1 Assembly and Maturation Andrew Miranker Beta-2-microglobulin Alex Bohm Poly(A) polymerase RNA complex Thomas Steitz Phi29 DNA polymerase and Terminal Protein Karen Allen Structure-function detemination of the type III haloacid dehalogenase (HAD) superfamilymember: PSPTO2114 Qinghua Wang Low-pH influenza B virus hemagglutinin Brenda Schulman Studies of Proteins Involved in Childhood Leukemias: Alone and with Inhibitors David Rodgers Insulysin Jurgen Sygusch Crystal structure of the plant transcription factor StWhy1 complexed with DNA Xiangpeng Kong Structural studies of DNA replication initiation Ronen Marmorstein Interaction of alpha- and beta-spectrin Zhaohui Xu Structure and function studies of proteins involved in exocytosis Da Neng Wang Structure and Mechanism of Glycerol-3-Phosphate Transporter Christopher Miller Membrane Transporters Jianhua Fu Pol2-Cap Young Chul Park Structural study of caspase-recruitment domains Karen Allen Structure and Mechanism of Hotdog-Fod Thioesterases Elias Lolis Macrophage Migration Inhibitory Factor Jane Ladner PhzM, an S-adenosylmethionine dependent methyltransferase Paresh Sanghani Structure-activity relationships in formaldehyde dehydrogenase David Gallagher cAMP receptor protein from Mycobacterium tuberculosis Jurgen Sygusch Leishmania mexicana aldolase inhibition studies Kannan Natarajan Structures of T cell receptors, unliganded and in complex with MHC molecules William Royer Viral Interferon Regulatory Factor 1 Alba Guarne Cabello DNA segregation proteins Christopher Hill 20S Archaeal proteosome Christopher Hill AIP1 and p9 peptide Carolyn Cohen Crystal structure of SqS1 version 2