Preclinical evaluation of F-18 fluoroethyltriazolyl PEGstilbenes as potential PET imaging agents for Alzheimers disease

阿尔茨海默病(AD)是最常见的痴呆症，由于人口老龄化，它正在给卫生系统带来越来越大的负担。淀粉样斑块被认为是AD的标志，体内检测淀粉样斑块的技术将是一个突破，不仅对于AD的诊断，而且对于开发治疗AD的药物都是一个突破。核医学可以非侵入性地成像组织功能。本项目旨在开发新的显像剂以提高AD的诊断水平。

Alzheimer's disease (AD) is the most common form of dementia and is becoming am ever increasing burden to the health system due to the aging of our population. Amyloid plaques are considered the hallmark of AD and a technique for their detection in vivo would be a breakthrough, not only for the diagnosis of AD but also for the development of drugs against AD. Nuclear medicine can image tissue function non-invasively. This project aims to develop new imaging agents to improve diagnosis of AD.