PET imaging agents for the differential diagnosis of hypoxic tumors

用于鉴别诊断缺氧肿瘤的 PET 显像剂

• 批准号: nhmrc : 1011418
• 负责人: A/Pr Henri Tochon-Danguy
• 金额: $ 39.04万
• 依托单位: Austin Hospital Medical Research Foundation
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pet-imaging-agents-hypoxic-tumors/109583
• 关键词: PET; imaging; agents; differential; diagnosis

Choosing the best type of treatment from the ever increasing arsenal of chemotherapeutic agents against cancer is of critical importance. Tumor hypoxia requires specialized treatment and patient selection. Current PET imaging agents cannot differentiate between severely and mildly hypoxic tumors. We have found a new agent that can detect mildly hypoxic tumors and the aim of this grant application is to further develop this radiotracer to improve image quality and reliability of the diagnosis.

从不断增加的抗癌化疗药物中选择最佳治疗类型至关重要。肿瘤缺氧需要专门的治疗和患者选择。目前的PET显像剂不能区分严重和轻度缺氧肿瘤。我们已经发现了一种新的试剂，可以检测轻度缺氧肿瘤，这项资助申请的目的是进一步开发这种放射性示踪剂，以提高图像质量和诊断的可靠性。