Prospective clinical research of radiation response to high-dose radiotherapy in lung tumours and surrounding normal tissue using functional imaging biomarker assessments

使用功能成像生物标志物评估对肺肿瘤和周围正常组织的高剂量放射治疗的放射反应进行前瞻性临床研究

• 批准号: nhmrc : 1038399
• 负责人: A/Pr Shankar Siva
• 金额: $ 8.02万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/prospective-clinical-research-biomarker-assessments/111132
• 关键词: Prospective; clinical; research; radiation; response

Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radiotherapy dose escalation. However a major limitation to dose escalation is the associated toxicity to the lung. At present, the mechanisms of lung toxicity are incompletely understood. This research will investigate biomarkers of radiation response in patients receiving high-dose radiotherapy to the lung by using state-of-the-art scanning techniques.

放射疗法是一种潜在的肺癌治疗方法。为了改善结果，现代研究工作集中在放射治疗剂量递增上。然而，剂量递增的主要限制是对肺的相关毒性。目前，肺毒性的机制还不完全清楚。本研究将通过使用最先进的扫描技术来研究接受高剂量放射治疗的患者的放射反应生物标志物。