Protecting the endothelial glycocalyx to improve transplant rates and outcomes

保护内皮糖萼以提高移植率和结果

• 批准号: nhmrc : GNT1103862
• 负责人: A/Pr Peter Hopkins
• 金额: $ 72.52万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protecting-endothelial-glycocalyx-rates-outcomes/1346309
• 关键词: Protecting; endothelial; glycocalyx; improve; transplant

A tiny, previously overlooked, structure called the endothelial glycocalyx (EG) is now known to ‘waterproof’ blood vessels. This grant extends our exciting preliminary data in the field of lung transplantation, where we have shown that EG loss is the main cause of a poorly functioning organ, to develop new tests of lung and kidney function, as well as treatments to resuscitate marginal organs outside the body, so improving access to and the safety of transplantation.

一个微小的，以前被忽视的，被称为内皮糖萼（EG）的结构现在被称为“防水”血管。这项资助扩展了我们在肺移植领域令人兴奋的初步数据，我们已经证明EG损失是器官功能不良的主要原因，开发了肺和肾功能的新测试，以及在体外复苏边缘器官的治疗方法，从而提高了移植的可及性和安全性。