An in depth analysis of clinical and virological outcomes of 2 strategies for the antiretroviral salvage of first-line regimen virological failure for HIV-1 infection tested in an Australian-led randomised, international, multi-centre clinical trial

在一项澳大利亚主导的随机、国际、多中心临床试验中，对两种一线治疗方案病毒学失败的 HIV-1 感染挽救策略的临床和病毒学结果进行了深入分析

• 批准号: nhmrc : 1068383
• 负责人: Prof Mark Boyd
• 金额: $ 28.12万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-depth-analysis-clinical-trial/455341
• 关键词: depth; analysis; clinical; virological; outcomes

The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.

最近完成的澳大利亚主导的二线试验是第一项高质量的研究，为标准初始治疗失败后抗艾滋病毒药物鸡尾酒组合的政策建议提供了可靠的证据。该奖项将支持研究人员进一步完善我们对如何管理二线治疗的理解，包括测试低成本技术在大多数艾滋病毒感染者生活的资源有限环境中的应用的建议。