The early inflammatory response to virulent and avirulent influenza viruses

对强毒力和无毒力流感病毒的早期炎症反应

• 批准号: nhmrc : 400226
• 负责人: Prof Patrick Reading
• 金额: $ 16.85万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/early-inflammatory-response-influenza-viruses/100059
• 关键词: early; inflammatory; response; virulent; avirulent

Innate immune mechanisms are vital components of host defences against pathogens. In this proposal I aim to investigate the particular mechanisms that operate in early defence against influenza virus infection and compare the ability of virulent and avirulent virus strains to (i) be recognized by components of the innate immune system, and (ii) to trigger an early inflammatory response to infection. It is anticipated that virulent virus strains have adapted to avoid recognition by innate cells such as macrophages. By avoiding this route of uptake and destruction, the virus is free to infect and replicate in other cells of the respiratory tract. Furthermore, by evading macrophage entry, the virus avoids triggering the release of early inflammatory mediators from these cells and this may affect both the speed and the magnitude of the subsequent inflammatory response. This study will contribute to a greater understanding of factors involved in initiating and regulating inflammation in the respiratory tract following viral infection. Furthermore, the findings may provide new insights into mechanisms of virulence of influenza and other enveloped viruses.

先天免疫机制是宿主防御病原体的重要组成部分。在本提案中，我的目的是研究早期防御流感病毒感染的特定机制，并比较强毒力和无毒力病毒株的能力（i）被先天免疫系统的组成部分识别，以及（ii）触发对感染的早期炎症反应。预计强毒病毒株已适应避免被巨噬细胞等先天细胞识别。通过避免这种摄取和破坏途径，病毒可以自由感染呼吸道的其他细胞并在其中复制。此外，通过逃避巨噬细胞进入，病毒避免触发这些细胞释放早期炎症介质，这可能会影响随后炎症反应的速度和程度。这项研究将有助于更好地了解病毒感染后引发和调节呼吸道炎症的因素。此外，这些发现可能为流感和其他包膜病毒的毒力机制提供新的见解。