Soluble inhibitors of influenza virus in the airway fluids of mice, ferrets and humans.

小鼠、雪貂和人类气道液中流感病毒的可溶性抑制剂。

• 批准号: nhmrc : 1032079
• 负责人: Prof Patrick Reading
• 金额: $ 26.99万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/soluble-inhibitors-influenza-ferrets-humans/110839
• 关键词: Soluble; inhibitors; influenza; virus; airway

This study will characterize the ability of soluble proteins in airway secretions to recognize and destroy influenza viruses. As many of our insights regarding influenza pathogenesis are derived from studies in animal models, we will characterize the importance of proteins in airway fluids from mice and ferrets, as well as from humans. These findings will be of particular importance when assessing the relevance of particular animal models to understanding human disease.

本研究将描述气道分泌物中可溶性蛋白识别和破坏流感病毒的能力。由于我们对流感发病机制的许多见解都来自动物模型的研究，我们将描述小鼠和雪貂以及人类气道液体中蛋白质的重要性。在评估特定动物模型与理解人类疾病的相关性时，这些发现将具有特别重要的意义。