The functional role of Slit-Robo signaling in interneuron migration.

Slit-Robo 信号在神经元间迁移中的功能作用。

• 批准号: nhmrc : 400479
• 负责人: A/Pr Jason Howitt
• 金额: $ 11.5万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-role-slit-interneuron-migration/114678
• 关键词: functional; role; Slit; Robo; signaling

In the developing brain of vertebrates interneurons undergo directed migration to form complex networks that result in the regulation of neuronal processes. Failure or imbalance of these neuronal networks is known to cause pilepsy and mental retardation. The aim of this project is to investigate the guidance cues, specifically Slit-Robo signalling, that direct the migration of interneurons within the brain.

在脊椎动物发育中的大脑中，中间神经元经历定向迁移，形成复杂的网络，从而导致神经元过程的调节。众所周知，这些神经元网络的故障或失衡会导致癫痫和智力低下。这个项目的目的是研究指导大脑内中间神经元迁移的引导信号，特别是Sit-Robo信号。