THE ROLE OF UBIQUITIN LIGASE ADAPTOR PROTEIN NDFIP1 IN NEURONAL DEVELOPMENT
THE ROLE OF UBIQUITIN LIGASE ADAPTOR PROTEIN NDFIP1 IN NEURONAL DEVELOPMENT
批准号:
nhmrc : 1008787
负责人:
A/Pr Jason Howitt
金额:
$38.8万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Many brain diseases are characterized by faulty connections between nerve cells (neurons), in some cases caused by the inability to remove unwanted proteins from the neuron. This function is carried out by the ubiquitin-proteasome system (UPS). We have evidence that a UPS protein called Ndfip1 is important for forming functional brain circuits. We aim to discover whether neuron growth, branching and connectivity is promoted by Ndfip1 targeting of PTEN (phosphatase with tensin homology) to the UPS.
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