THE ROLE OF UBIQUITIN LIGASE ADAPTOR PROTEIN NDFIP1 IN NEURONAL DEVELOPMENT

泛素连接酶接头蛋白 NDFIP1 在神经元发育中的作用

• 批准号: nhmrc : 1008787
• 负责人: A/Pr Jason Howitt
• 金额: $ 38.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-ubiquitin-ligase-neuronal-development/109340
• 关键词: ROLE; UBIQUITIN; LIGASE; ADAPTOR; PROTEIN

Many brain diseases are characterized by faulty connections between nerve cells (neurons), in some cases caused by the inability to remove unwanted proteins from the neuron. This function is carried out by the ubiquitin-proteasome system (UPS). We have evidence that a UPS protein called Ndfip1 is important for forming functional brain circuits. We aim to discover whether neuron growth, branching and connectivity is promoted by Ndfip1 targeting of PTEN (phosphatase with tensin homology) to the UPS.

许多脑部疾病的特征是神经细胞（神经元）之间的连接错误，在某些情况下是由于无法从神经元中去除不需要的蛋白质而引起的。该功能由泛素蛋白酶体系统（UPS）执行。我们有证据表明，一种名为 Ndfip1 的 UPS 蛋白对于形成功能性大脑回路非常重要。我们的目标是发现 Ndfip1 靶向 PTEN（具有张力蛋白同源性的磷酸酶）是否能促进神经元的生长、分支和连接。