How can trafficking of the tumour suppressor PTEN affect normal and abnormal brain development?

肿瘤抑制因子 PTEN 的运输如何影响正常和异常的大脑发育？

• 批准号: nhmrc : 1066895
• 负责人: A/Pr Jason Howitt
• 金额: $ 39.34万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/trafficking-tumour-suppressor-brain-development/455266
• 关键词: How; trafficking; tumour; suppressor; PTEN

Autism is a complex neurodevelopmental disorder that is estimated to affect 1 in every 100 children. Currently we have no medical treatments to cure the disease. PTEN is a tumor suppressor that has been genetically linked to autism as it functions to inhibit cell growth that can result in abnormal brain development. In this grant we aim to study the location and function of PTEN and how failure of this system can result in neurodevelopmental diseases such as autism.

自闭症是一种复杂的神经发育障碍，据估计每100个儿童中就有1个患有自闭症。目前我们没有治疗这种疾病的药物。PTEN是一种肿瘤抑制因子，在基因上与自闭症有关，因为它的功能是抑制可能导致大脑异常发育的细胞生长。在这项资助中，我们的目标是研究PTEN的位置和功能，以及该系统的失败如何导致神经发育疾病，如自闭症。