The interaction between the host and pathogen genetics in susceptibility to pulmonary tuberculosis

宿主和病原体遗传学在肺结核易感性中的相互作用

• 批准号: nhmrc : 1056689
• 负责人: A/Pr Kathryn Holt
• 金额: $ 26.02万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interaction-host-pathogen-pulmonary-tuberculosis/112576
• 关键词: interaction; between; host; pathogen; genetics

People infected with the bacteria causing tuberculosis (TB) have different clinical fates. Some people remain well with dormant infections, some get lung disease and survive, others die. We are investigating the interplay between the human host and the bacteria causing disease by identifying genetic variants in both. This will enable us to determine what is important in the defence against this disease. Knowledge of the different TB disease processes is critical for future rational design of new TB vaccines and treatments.

感染结核病（TB）细菌的人有不同的临床命运。有些人保持良好的休眠感染，有些人得了肺病并存活下来，其他人死亡。我们正在研究人类宿主和致病细菌之间的相互作用，方法是识别两者的遗传变异。这将使我们能够确定在预防这种疾病方面什么是重要的。了解不同的结核病发病过程对于今后合理设计新的结核病疫苗和治疗方法至关重要。