Molecular networks and genomics of host response in typhoid fever

伤寒宿主反应的分子网络和基因组学

• 批准号: nhmrc : GNT1101728
• 负责人: A/Pr Kathryn Holt
• 金额: $ 48.78万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-networks-genomics-typhoid-fever/1346173
• 关键词: Molecular; networks; genomics; host; response

Typhoid fever affects 25 million people annually and is caused by systemic infection with Salmonella Typhi or Paratyphi. With this proposal, we will characterise how different individuals respond differently to typhoid, what ramifications this has for systemic Salmonella infection in humans, and how typhoid can be clinically identified early on, thus giving the patient the best possible chance to avoid complications, injury and potential death.

伤寒每年影响2500万人，由伤寒沙门氏菌或副伤寒的全身感染引起。有了这个建议，我们将研究不同的人对伤寒的反应如何不同，这对人类系统性沙门氏菌感染有什么影响，以及如何在早期临床上识别伤寒，从而为患者提供最好的机会，以避免并发症，伤害和潜在的死亡。