Systems biology of asthma development in early childhood

儿童早期哮喘发展的系统生物学

• 批准号: nhmrc : 1049539
• 负责人: A/Pr Kathryn Holt
• 金额: $ 50.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-biology-asthma-early-childhood/112090
• 关键词: Systems; biology; asthma; development; early

Recent studies have established that both human genetic susceptibility and viral infections during early childhood are important drivers of asthma development. It has also been noted that asthmatics’ airways are colonized with different bacteria to non-asthmatics. In this project we will examine how genetic susceptibility and interactions between bacteria and viruses in children's airways promote the development of allergy and asthma.

最近的研究证实，人类的遗传易感性和儿童早期的病毒感染都是哮喘发生的重要驱动因素。人们还注意到，与非哮喘患者相比，哮喘患者的呼吸道被不同的细菌定植。在这个项目中，我们将研究儿童呼吸道中细菌和病毒之间的遗传易感性和相互作用如何促进过敏和哮喘的发展。