Prevention of asthma in young children via immunostimulation

通过免疫刺激预防幼儿哮喘

• 批准号: nhmrc : 1041983
• 负责人: A/Pr Kathryn Holt
• 金额: $ 45.32万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/prevention-asthma-young-children-immunostimulation/111424
• 关键词: Prevention; asthma; young; children; via

Persistent asthma is a major problem for Australia yet none of the current therapies do more that control the condition. The long-term solution is to prevent asthma from progressing to the persistent form. The major risk factors are: family history, early allergy and recurrent severe lower respiratory infections (sLRI) in the early life. We will conduct a randomized clinical trial to prevent sLRI using a novel bacterial-derived immunostimulant in infants at high risk of developing asthma.

持续性哮喘是澳大利亚的一个主要问题，但目前没有一种治疗方法能更好地控制病情。长期的解决办法是防止哮喘发展成持续性的形式。主要危险因素有：家族史、早期过敏和生命早期复发性严重下呼吸道感染（sLRI）。我们将进行一项随机临床试验，在哮喘高风险的婴儿中使用一种新型细菌来源的免疫刺激剂来预防sLRI。