Apoptosis and Stem/Progenitor Cells in the Development and Treatment of Cancer

细胞凋亡和干细胞/祖细胞在癌症发展和治疗中的作用

• 批准号: nhmrc : GNT1113133
• 负责人: A/Pr Guillaume Lessene
• 金额: $ 2180.96万
• 依托单位国家: 澳大利亚
• 项目类别: Programs
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/apoptosis-stemprogenitor-cells-treatment-cancer/1346831
• 关键词: Apoptosis; Stem; Progenitor; Cells; Development

To improve cancer therapy, we are studying two cancer hallmarks. The first is excessive cell survival. To combat this, we are developing drugs with commercial partners that directly activate the cell's death machinery. The second hallmark is inexorable proliferation, akin to that of stem cells, which can generate entire tissues, as we showed for the breast. ‘Rogue’ stem-like cells may initiate certain cancers. We hope to advance cancer therapy by identifying such cells and drugs that kill them.

为了改进癌症治疗，我们正在研究两个癌症标志。首先是细胞过度存活。为了应对这一问题，我们正在与商业合作伙伴开发直接激活细胞死亡机制的药物。第二个特点是不可阻挡的增殖，类似于干细胞，它可以生成完整的组织，就像我们在乳房展示的那样。“无赖”类干细胞可能会引发某些癌症。我们希望通过识别这种细胞和杀死它们的药物来推进癌症治疗。