The molecular mechanism of ion-coupled transport in the brain

大脑中离子耦合传输的分子机制

• 批准号: nhmrc : 571093
• 负责人: A/Pr Renae Ryan
• 金额: $ 29.43万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-mechanism-ion-transport-brain/116150
• 关键词: molecular; mechanism; ion; coupled; transport

Cells in the brain communicate through chemical signals called neurotransmitters. Neurotransmitter transporters reside in the membranes of cells and are responsible for regulating levels of these chemicals in the brain. They play an important role in the normal function of the human brain but their dysfunction is responsible for many diseases including Alzheimer's disease and motor neuron disease. It is crucial to understand how these proteins work in both normal and disease states.

大脑中的细胞通过一种叫做神经递质的化学信号进行交流。神经递质转运体存在于细胞膜中，负责调节大脑中这些化学物质的水平。它们在人类大脑的正常功能中起着重要作用，但它们的功能障碍是许多疾病的原因，包括阿尔茨海默病和运动神经元疾病。了解这些蛋白质在正常和疾病状态下的工作原理是至关重要的。